| Literature DB >> 15808678 |
R B Elliott1, L Escobar, R Calafiore, G Basta, O Garkavenko, A Vasconcellos, C Bambra.
Abstract
Neonatal porcine islets within alginate microcapsules transplanted intraperitoneally (IP) or within semi-permeable macrocapsules (TheraCyte) and transplanted subcutaneously (SC) survive and reverse diabetes for up to 16 weeks in diabetic autoimmune nonobese diabetic (NOD) mice. The islets in microcapsules transplanted IP into nondiabetic cynomolgus monkeys survived for 8 weeks. Similar results were shown with islets transplanted in TheraCytes. Neither species showed adverse effects or evidence of infection with porcine endogenous retroviruses or other endemic pig viruses. Proof of principle is illustrated for successful xenotransplantation in humans.Entities:
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Year: 2005 PMID： 15808678 DOI： 10.1016/j.transproceed.2004.12.198
Source DB: PubMed Journal: Transplant Proc ISSN： 0041-1345 Impact factor: 1.066