| Literature DB >> 15808480 |
Ashoke Sharon1, Ramendra Pratap, Priti Tiwari, Arvind Srivastava, P R Maulik, Vishnu Ji Ram.
Abstract
A series of 5-[(5-aryl-1H-pyrazol-3-yl)methyl]-1H-tetrazoles 3a-h have been synthesized and evaluated for their in vivo antihyperglycemic activity. Some of the synthesized compounds have shown significant glucose lowering activity in male Sprague-Dawley rats in sucrose loaded model. These compounds were also evaluated for their peroxisome proliferator activated receptor gamma agonistic property, but none of them displayed any significant activity.Entities:
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Year: 2005 PMID： 15808480 DOI： 10.1016/j.bmcl.2005.02.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823