| Literature DB >> 15808477 |
Darren McKerrecher1, Joanne V Allen, Suzanne S Bowker, Scott Boyd, Peter W R Caulkett, Gordon S Currie, Christopher D Davies, Mark L Fenwick, Harold Gaskin, Emma Grange, Rod B Hargreaves, Barry R Hayter, Roger James, Keith M Johnson, Craig Johnstone, Clifford D Jones, Sarah Lackie, John W Rayner, Rolf P Walker.
Abstract
The identification, synthesis and SAR of a novel series of glucokinase activators is described. The interplay between lipophilicity, potency and physical properties is discussed, and compound 22 highlighted as having a suitable balance. In vivo pharmacokinetic and acute efficacy studies on this compound are also presented.Entities:
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Year: 2005 PMID： 15808477 DOI： 10.1016/j.bmcl.2005.01.087
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823