| Literature DB >> 15808457 |
James M Nyangulu1, Samantha L Hargreaves, Susan L Sharples, Simon P Mackay, Roger D Waigh, Olivier Duval, Eddie K Mberu, William M Watkins.
Abstract
Analogues of the antimalarial alkaloid nitidine have been prepared with high potency against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. Simple modifications, using an established synthetic route, resulted in an analogue with IC(50) below 5ng/mL against a chloroquine-sensitive strain of P. falciparum. N-Ethylethoxidine had IC(50) below 30ng/mL against both chloroquine-sensitive and chloroquine-resistant strains of P. falciparum.Entities:
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Year: 2005 PMID： 15808457 DOI： 10.1016/j.bmcl.2005.02.074
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823