| Literature DB >> 15808452 |
Alireza Foroumadi1, Shirin Pournourmohammadi, Fatemeh Soltani, Mitra Asgharian-Rezaee, Shahriar Dabiri, Arsalan Kharazmi, Abbas Shafiee.
Abstract
A series of 2-(5-nitro-2-furyl) and 2-(5-nitro-2-thienyl)-5-substituted-1,3,4-thiadiazoles (5a-d and 6a-j) were synthesized and evaluated against Leishmania major promastigotes using (3)H-thymidine incorporation. Most of the compounds showed activity better than the reference drug sodium stibogluconate (Pentostam). The most active compound was 6c (IC(50)=0.1 microM).Entities:
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Year: 2005 PMID： 15808452 DOI： 10.1016/j.bmcl.2005.02.073
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823