Literature DB >> 15808295

Cytokine production and modulation: comparison of patients with chronic fatigue syndrome and normal controls.

Akemi Tomoda1, Takako Joudoi, El-Mezayen Rabab, Tomoaki Matsumoto, T H Park, Teruhisa Miike.   

Abstract

We studied cytokine production in 15 patients with chronic fatigue syndrome (CFS) and 23 controls. CFS patients' peripheral blood mononuclear cells were cultured with lipopolysaccharide or phytohemagglutinin. Enzymatic immunoassay indicated cytokine concentration in culture supernatants. CFS patients showed significantly lower mRNA levels and transforming growth factor-beta1 (TGF-beta1) production. Cytokine dysregulation affects CFS pathogenesis. TGF-beta1 may aid treatment because it affects CFS inflammatory characteristics.

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Year:  2005        PMID： 15808295     DOI： 10.1016/j.psychres.2005.01.002

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  20 in total

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