| Literature DB >> 1580595 |
Abstract
Generalized resistance to thyroid hormone (GRTH) encompasses a heterogeneous group of conditions characterized by reduced responses of target tissues to thyroid hormone due to defects at the site of hormone action. In the majority of patients, GRTH is inherited as a dominant trait associated with mutations in the hormone-binding domain of the thyroid hormone receptor. GRTH serves as a prototype of other resistance syndromes for hormones that act via nuclear receptors.Entities:
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Year: 1992 PMID： 1580595 DOI： 10.1146/annurev.me.43.020192.002051
Source DB: PubMed Journal: Annu Rev Med ISSN： 0066-4219 Impact factor: 13.739