Literature DB >> 15804612

Quantitative measurement of events in the mammalian unfolded protein response.

Jie Shang1.   

Abstract

The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response. IRE1, PERK, ATF6, BiP, EDEM, lipid-linked oligosaccharides (LLOs), and XBP1 directly or indirectly participate in this process. This article provides methods used in our laboratory to quantitatively measure the accumulation of mRNAs encoding BiP and EDEM; splicing of XBP-1; cleavage of ATF6; inhibition of protein synthesis by PERK; and extension of LLOs under control and stress conditions.

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Year:  2005        PMID： 15804612     DOI： 10.1016/j.ymeth.2004.10.012

Source DB:  PubMed          Journal:  Methods        ISSN： 1046-2023            Impact factor:   3.608


  17 in total

Review 1.  Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis.

Authors:  Harikrishna Tanjore; Timothy S Blackwell; William E Lawson
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2012-01-27       Impact factor: 5.464

2.  Genetic background influences UPR but not PLP processing in the rumpshaker model of PMD/SPG2.

Authors:  M McLaughlin; S A Karim; P Montague; J A Barrie; D Kirkham; I R Griffiths; J M Edgar
Journal:  Neurochem Res       Date:  2006-08-31       Impact factor: 3.996

3.  Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways.

Authors:  Jennifer J Wolfson; Kerrie L May; Cheleste M Thorpe; Dakshina M Jandhyala; James C Paton; Adrienne W Paton
Journal:  Cell Microbiol       Date:  2008-04-21       Impact factor: 3.715

4.  Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs.

Authors:  William E Lawson; Dong-Sheng Cheng; Amber L Degryse; Harikrishna Tanjore; Vasiliy V Polosukhin; Xiaochuan C Xu; Dawn C Newcomb; Brittany R Jones; Juan Roldan; Kirk B Lane; Edward E Morrisey; Michael F Beers; Fiona E Yull; Timothy S Blackwell
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-13       Impact factor: 11.205

5.  Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis.

Authors:  Mary E Rinella; M Shaddab Siddiqui; Konstantina Gardikiotes; Jeanne Gottstein; Marc Elias; Richard M Green
Journal:  Hepatology       Date:  2011-07-27       Impact factor: 17.425

6.  Classical and neonatal Marfan syndrome mutations in fibrillin-1 cause differential protease susceptibilities and protein function.

Authors:  Ryan Kirschner; Dirk Hubmacher; Garud Iyengar; Jasvir Kaur; Christine Fagotto-Kaufmann; Dieter Brömme; Rainer Bartels; Dieter P Reinhardt
Journal:  J Biol Chem       Date:  2011-07-22       Impact factor: 5.157

7.  Approaches to imaging unfolded secretory protein stress in living cells.

Authors:  Patrick Lajoie; Elena N Fazio; Erik L Snapp
Journal:  Endoplasmic Reticulum Stress Dis       Date:  2014-01-01

8.  Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis.

Authors:  David S Grenda; Mark Murakami; Jhuma Ghatak; Jun Xia; Laurence A Boxer; David Dale; Mary C Dinauer; Daniel C Link
Journal:  Blood       Date:  2007-08-30       Impact factor: 22.113

9.  IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1.

Authors:  Jeffery A Thorpe; Steven R Schwarze
Journal:  Cell Stress Chaperones       Date:  2009-12-15       Impact factor: 3.667

10.  Tunicamycin suppresses cisplatin-induced HepG2 cell apoptosis via enhancing p53 protein nuclear export.

Authors:  Li-Juan Zhang; Zai-Quan Li; Ye-Peng Yang; Xiao-Wen Li; Jia-Fu Ji
Journal:  Mol Cell Biochem       Date:  2009-02-26       Impact factor: 3.396
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