| Literature DB >> 15804443 |
Yoshifumi Sonobe1, Izumi Yawata, Jun Kawanokuchi, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura.
Abstract
Production of IL-27 and other IL-12 family cytokines by murine microglia were examined using RT-PCR, real-time RT-PCR and Western blot analysis. We show for the first time that murine microglia produce IL-27 in response to lipopolysaccharide (LPS) and/or interferon-gamma. Primary microglia, but not their cell lines, also induce IL-12 and IL-23 upon above stimulation. Therefore, microglia may play a critical role initiating Th1 responses via producing IL-12 family cytokines in the brain.Entities:
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Year: 2005 PMID： 15804443 DOI： 10.1016/j.brainres.2005.01.100
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252