| Literature DB >> 15804433 |
Lenice K Becker1, Robson A S Santos, Maria José Campagnole-Santos.
Abstract
We evaluated the effect of physical training on the cardiovascular responses produced by angiotensin peptides at the rostroventrolateral medulla (RVLM) of non-anesthetized normotensive rats. The RVLM pressor effect induced by Ang II was significantly greater in trained rats, while, in contrast, the Ang-(1-7) pressor effect was significantly smaller in trained in comparison to sedentary rats. In addition, the RVLM microinjection of Losartan (AT1 Ang II receptor antagonist) or A-779 (Ang-(1-7) receptor antagonist) induced opposite effect in trained rats. These results show that exercise training induces a differential RVLM responsiveness to Ang peptides, which was corroborated by the selective antagonists, indicating that the RVLM is a site in the central nervous system involved in the adaptive mechanisms triggered during exercise training.Entities:
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Year: 2005 PMID： 15804433 DOI： 10.1016/j.brainres.2005.01.085
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252