BACKGROUND: Intra-arterial thrombolysis (IAT) for peri-coronary angiography (CA) stroke may be safe and efficacious. However, IAT may increase the risk of intracranial hemorrhage (ICH). METHODS: A retrospective study was performed involving 3 university hospitals. All peri-CA IAT-treated cases were identified. Patient demographics, stroke severity, angiographic findings, thrombolytic use, modified Rankin Scale (mRS), ICH, and mortality were determined. RESULTS: A total of 21 patients with post-left CA stroke were treated with IAT (mean age 71.8+/-12.3 years). Arterial occlusion was found in 14 (66.7%) and 7 (33.3%) of the anterior and posterior circulation, respectively. Mean time-to-therapy was 36+/-12 minutes from the time the neurological deficit was noted. mRS < or =2 occurred in 10 of 21 (48%) patients. Patients with younger age and shorter time-to-IAT had more complete arterial recanalization and clinical recovery. Symptomatic ICH occurred in 3 (14%) cases, and 4 (19%) patients died. CONCLUSIONS: Peri-CA IAT appears to be feasible and safe without increased risk of symptomatic ICH and death when compared with the previously reported IAT literature.
BACKGROUND: Intra-arterial thrombolysis (IAT) for peri-coronary angiography (CA) stroke may be safe and efficacious. However, IAT may increase the risk of intracranial hemorrhage (ICH). METHODS: A retrospective study was performed involving 3 university hospitals. All peri-CA IAT-treated cases were identified. Patient demographics, stroke severity, angiographic findings, thrombolytic use, modified Rankin Scale (mRS), ICH, and mortality were determined. RESULTS: A total of 21 patients with post-left CA stroke were treated with IAT (mean age 71.8+/-12.3 years). Arterial occlusion was found in 14 (66.7%) and 7 (33.3%) of the anterior and posterior circulation, respectively. Mean time-to-therapy was 36+/-12 minutes from the time the neurological deficit was noted. mRS < or =2 occurred in 10 of 21 (48%) patients. Patients with younger age and shorter time-to-IAT had more complete arterial recanalization and clinical recovery. Symptomatic ICH occurred in 3 (14%) cases, and 4 (19%) patients died. CONCLUSIONS: Peri-CA IAT appears to be feasible and safe without increased risk of symptomatic ICH and death when compared with the previously reported IAT literature.
Authors: Serge C Harb; George Thomas; Walid I Saliba; Georges N Nakhoul; Ayman A Hussein; Valeria E Duarte; Mandeep Bhargava; Bryan Baranowski; Patrick Tchou; Thomas Dresing; Thomas Callahan; Mohamed Kanj; Andrea Natale; Bruce D Lindsay; Oussama M Wazni Journal: J Interv Card Electrophysiol Date: 2012-12-22 Impact factor: 1.900
Authors: Pooja Khatri; Robert A Taylor; Vanessa Palumbo; Venkatakrishna Rajajee; Jeffrey M Katz; Julio A Chalela; Ann Geers; Joseph Haymore; Daniel M Kolansky; Scott E Kasner Journal: J Am Coll Cardiol Date: 2008-03-04 Impact factor: 24.094
Authors: Jacob Cherian; Christopher Cronkite; Visish Srinivasan; Maryam Haider; Ali S Haider; Peter Kan; Jeremiah N Johnson Journal: Brain Circ Date: 2021-12-21