P Das1, A K Ng, M A Stevenson, P M Mauch. 1. Department of Radiation Oncology, U.T. M.D. Anderson Cancer Center, Houston, TX 77030, USA. PrajDas@mdanderson.org
Abstract
BACKGROUND: Hodgkin's disease survivors have a high risk of subsequently developing thoracic cancers. Our goal was to evaluate the prognosis and treatment outcomes of thoracic cancers after Hodgkin's disease. PATIENTS AND METHODS: Thirty-three patients treated for Hodgkin's disease at Harvard-affiliated hospitals subsequently developed small-cell lung carcinoma, non-small-cell lung carcinoma (NSCLC) or mesothelioma. Information was obtained from medical records about the initial treatment for Hodgkin's disease, any salvage therapy, smoking history, and the stage, histology, treatment and survival for thoracic cancers. RESULTS: Of the 33 patients, 29 (88%) had a history of radiotherapy to the thorax, 17 (52%) had received alkylating chemotherapy, and 24 (73%) had a known history of smoking. The median time between diagnosis of Hodgkin's disease and diagnosis of thoracic cancer was 17.3 years (range 1.2-27.9 years). Among patients with NSCLC and a known stage, 85% presented with stage III or stage IV disease. Among patients whose treatment details were available, 40% underwent surgery, 40% received radiotherapy and 65% received chemotherapy. The median survival was 9 months (range 1-47 months). CONCLUSIONS: Most patients with thoracic cancers after Hodgkin's disease have a history of exposure to risk factors and present at an advanced stage. Patients with thoracic cancers after Hodgkin's disease have a poor survival.
BACKGROUND:Hodgkin's disease survivors have a high risk of subsequently developing thoracic cancers. Our goal was to evaluate the prognosis and treatment outcomes of thoracic cancers after Hodgkin's disease. PATIENTS AND METHODS: Thirty-three patients treated for Hodgkin's disease at Harvard-affiliated hospitals subsequently developed small-cell lung carcinoma, non-small-cell lung carcinoma (NSCLC) or mesothelioma. Information was obtained from medical records about the initial treatment for Hodgkin's disease, any salvage therapy, smoking history, and the stage, histology, treatment and survival for thoracic cancers. RESULTS: Of the 33 patients, 29 (88%) had a history of radiotherapy to the thorax, 17 (52%) had received alkylating chemotherapy, and 24 (73%) had a known history of smoking. The median time between diagnosis of Hodgkin's disease and diagnosis of thoracic cancer was 17.3 years (range 1.2-27.9 years). Among patients with NSCLC and a known stage, 85% presented with stage III or stage IV disease. Among patients whose treatment details were available, 40% underwent surgery, 40% received radiotherapy and 65% received chemotherapy. The median survival was 9 months (range 1-47 months). CONCLUSIONS: Most patients with thoracic cancers after Hodgkin's disease have a history of exposure to risk factors and present at an advanced stage. Patients with thoracic cancers after Hodgkin's disease have a poor survival.
Authors: Alfonso Fiorelli; Antonio D'Andrilli; Annalisa Carlucci; Giovanni Vicidomini; Domenico Loizzi; Nicoletta Pia Ardò; Rita Daniela Marasco; Luigi Ventura; Luca Ampollini; Paolo Carbognani; Giovanni Bocchialini; Filippo Lococo; Massimiliano Paci; Teresa Severina Di Stefano; Francesco Ardissone; Matteo Gagliasso; Paolo Mendogni; Lorenzo Rosso; Alessandra Mazzucco; Camilla Vanni; Beatrice Trabalza Marinucci; Rossella Potenza; Alberto Matricardi; Mark Ragusa; Valentina Tassi; Marco Anile; Camilla Poggi; Nicola Serra; Antonello Sica; Mario Nosotti; Francesco Sollitto; Federico Venuta; Erino Angelo Rendina; Francesco Puma; Mario Santini Journal: Transl Lung Cancer Res Date: 2020-02