Literature DB >> 15797830

Cholesterol homeostasis in neurons and glial cells.

Jean E Vance1, Hideki Hayashi, Barbara Karten.   

Abstract

Cholesterol is highly enriched in the brain compared to other tissues. Essentially all cholesterol in the brain is synthesized endogenously since plasma lipoproteins are unable to cross the blood-brain barrier. Cholesterol is transported within the central nervous system in the form of apolipoprotein E-containing lipoprotein particles that are secreted mainly by glial cells. Cholesterol is excreted from the brain in the form of 24-hydroxycholesterol. Apolipoprotein E and cholesterol have been implicated in the formation of amyloid plaques in Alzheimer's disease. In addition, the progressive neurodegenerative disorder Niemann-Pick C disease is characterized by defects in intracellular trafficking of cholesterol.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15797830     DOI： 10.1016/j.semcdb.2005.01.005

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  59 in total

1.  Generation of a human neuronal stable cell model for niemann-pick C disease by RNA interference.

Authors:  Laura Rodríguez-Pascau; Maria Josep Coll; Josefina Casas; Lluïsa Vilageliu; Daniel Grinberg
Journal:  JIMD Rep       Date:  2011-11-01

Review 2.  Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis.

Authors:  W Gibson Wood; Ling Li; Walter E Müller; Gunter P Eckert
Journal:  J Neurochem       Date:  2014-01-02       Impact factor: 5.372

3.  DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism.

Authors:  Martina Zikova; Alicia Corlett; Zdenka Bendova; Petr Pajer; Petr Bartunek
Journal:  Mol Endocrinol       Date:  2009-01-29

4.  Donepezil effects on cholesterol and oxysterol plasma levels of Alzheimer's disease patients.

Authors:  Alana C Costa; Helena P G Joaquim; Valéria S Nunes; Daniel S Kerr; Guilherme S Ferreira; Orestes V Forlenza; Wagner F Gattaz; Leda Leme Talib
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2017-08-31       Impact factor: 5.270

5.  Necroptosis-like Neuronal Cell Death Caused by Cellular Cholesterol Accumulation.

Authors:  Takeshi Funakoshi; Toshihiko Aki; Masateru Tajiri; Kana Unuma; Koichi Uemura
Journal:  J Biol Chem       Date:  2016-10-18       Impact factor: 5.157

Review 6.  Cholesterol-metabolizing cytochromes P450: implications for cholesterol lowering.

Authors:  Irina A Pikuleva
Journal:  Expert Opin Drug Metab Toxicol       Date:  2008-11       Impact factor: 4.481

7.  Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.

Authors:  Joanna M Karasinska; Franz Rinninger; Dieter Lütjohann; Piers Ruddle; Sonia Franciosi; Janine K Kruit; Roshni R Singaraja; Veronica Hirsch-Reinshagen; Jianjia Fan; Liam R Brunham; Nagat Bissada; Rajasekhar Ramakrishnan; Cheryl L Wellington; John S Parks; Michael R Hayden
Journal:  J Neurosci       Date:  2009-03-18       Impact factor: 6.167

Review 8.  Sphingolipids in neurodegeneration (with focus on ceramide and S1P).

Authors:  Guanghu Wang; Erhard Bieberich
Journal:  Adv Biol Regul       Date:  2018-09-22

9.  Cholesterol and perhaps estradiol protect against corticosterone-induced hippocampal CA3 dendritic retraction in gonadectomized female and male rats.

Authors:  J B Ortiz; K J McLaughlin; G F Hamilton; S E Baran; A N Campbell; C D Conrad
Journal:  Neuroscience       Date:  2013-04-22       Impact factor: 3.590

10.  Cardiovascular dementia - a different perspective.

Authors:  Udhaya Kumari; Klaus Heese
Journal:  Open Biochem J       Date:  2010-03-26
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.