| Literature DB >> 15797790 |
M G Quaglia1, E Donati, S Fanali, E Bossù, A Montinaro, F Buiarelli.
Abstract
Diltiazem (DTZ) is an optically active calcium channel blocker having a benzodiazepine structure. The drug used in therapy is (+)-cis-diltiazem with configuration (2S,3S). To describe the analytical profile of DTZ different stationary phases (RP-18, RP-8, monolithic support) were tested. The best separation of DTZ from A, B, E and F was obtained using as stationary phase a RP-8 or a monolithic RP-18. The characterization of impurities was carried out using two analytical systems, HPLC and HPLC/MS.Entities:
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Year: 2005 PMID： 15797790 DOI： 10.1016/j.jpba.2004.11.050
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935