Literature DB >> 15797613

Human antisense genes have unusually short introns: evidence for selection for rapid transcription.

Jianjun Chen1, Miao Sun, Laurence D Hurst, Gordon G Carmichael, Janet D Rowley.   

Abstract

We suggest that small introns are favored in genes requiring a minimal response time ('nimble' genes), and that antisense genes might be prime candidates for such nimble genes. In this article, we show that antisense genes have significantly shorter introns than all other gene categories, which supports our proposal that the short introns of antisense genes might be functionally important and integrally related to their potential role in efficient gene regulation.

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Year:  2005        PMID: 15797613     DOI: 10.1016/j.tig.2005.02.003

Source DB:  PubMed          Journal:  Trends Genet        ISSN: 0168-9525            Impact factor:   11.639


  35 in total

1.  The small introns of antisense genes are better explained by selection for rapid transcription than by "genomic design".

Authors:  Jianjun Chen; Miao Sun; Janet D Rowley; Laurence D Hurst
Journal:  Genetics       Date:  2005-09-02       Impact factor: 4.562

Review 2.  Genome-wide natural antisense transcription: coupling its regulation to its different regulatory mechanisms.

Authors:  Michal Lapidot; Yitzhak Pilpel
Journal:  EMBO Rep       Date:  2006-12       Impact factor: 8.807

3.  Highly expressed genes are associated with inverse antisense transcription in mouse.

Authors:  Andras Györffy; Pawel Surowiak; Zsolt Tulassay; Balazs Györffy
Journal:  J Genet       Date:  2007-08       Impact factor: 1.166

4.  "Genome design" model: evidence from conserved intronic sequence in human-mouse comparison.

Authors:  Alexander E Vinogradov
Journal:  Genome Res       Date:  2006-02-03       Impact factor: 9.043

5.  Expression profile and 5'-terminal structure of Arabidopsis antisense transcripts expressed in seeds.

Authors:  Masanori Okamoto; Motoaki Seki
Journal:  Plant Signal Behav       Date:  2011-05-01

6.  Higher frequency of intron loss from the promoter proximally paused genes of Drosophila melanogaster.

Authors:  Li Jiang; Xue-Nan Li; Deng-Ke Niu
Journal:  Fly (Austin)       Date:  2014       Impact factor: 2.160

7.  Genome-wide functional analysis of human 5' untranslated region introns.

Authors:  Can Cenik; Adnan Derti; Joseph C Mellor; Gabriel F Berriz; Frederick P Roth
Journal:  Genome Biol       Date:  2010-03-11       Impact factor: 13.583

8.  Selection for the compactness of highly expressed genes in Gallus gallus.

Authors:  You S Rao; Zhang F Wang; Xue W Chai; Guo Z Wu; Ming Zhou; Qing H Nie; Xi Q Zhang
Journal:  Biol Direct       Date:  2010-05-14       Impact factor: 4.540

9.  Exon definition as a potential negative force against intron losses in evolution.

Authors:  Deng-Ke Niu
Journal:  Biol Direct       Date:  2008-11-13       Impact factor: 4.540

10.  In plants, expression breadth and expression level distinctly and non-linearly correlate with gene structure.

Authors:  Hangxing Yang
Journal:  Biol Direct       Date:  2009-11-21       Impact factor: 4.540

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