Literature DB >> 15797611

The complexity of genetic variation in a simple immune system.

Dominic P Kwiatkowski1.   

Abstract

Fruitflies derived from a wild population vary in their resistance to infection with the bacterial pathogen Serratia marcescens. A survey of nucleotide diversity in 21 genes involved in innate immunity concluded that 16 genes had polymorphisms associated with resistance to this specific pathogen. However, the effects of individual polymorphisms on the resistance phenotype were modest, and epistatic interactions appeared to be common. What might these findings tell us about genetic resistance to infection in humans?

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Year:  2005        PMID： 15797611     DOI： 10.1016/j.tig.2005.02.002

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  7 in total

Review 1.  Reconstructing immune phylogeny: new perspectives.

Authors:  Gary W Litman; John P Cannon; Larry J Dishaw
Journal:  Nat Rev Immunol       Date:  2005-11       Impact factor: 53.106

2.  Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors.

Authors:  Gary W Litman; John P Cannon; Larry J Dishaw; Robert N Haire; Donna D Eason; Jeffrey A Yoder; Jose Hernandez Prada; David A Ostrov
Journal:  Immunol Res       Date:  2007       Impact factor: 2.829

Review 3.  Protective Innate Immune Variants in Racial/Ethnic Disparities of Breast and Prostate Cancer.

Authors:  LaCreis R Kidd; K Sean Kimbro; Susan T Yeyeodu
Journal:  Cancer Immunol Res       Date:  2019-09       Impact factor: 11.151

Review 4.  Zoonotic Potential of Emerging Paramyxoviruses: Knowns and Unknowns.

Authors:  Patricia A Thibault; Ruth E Watkinson; Andres Moreira-Soto; Jan F Drexler; Benhur Lee
Journal:  Adv Virus Res       Date:  2017-02-02       Impact factor: 9.937

Review 5.  The water flea Daphnia--a 'new' model system for ecology and evolution?

Authors:  Angelika Stollewerk
Journal:  J Biol       Date:  2010-01-13

6.  Investigation of host candidate malaria-associated risk/protective SNPs in a Brazilian Amazonian population.

Authors:  Simone da Silva Santos; Taane G Clark; Susana Campino; Martha Cecília Suarez-Mutis; Kirk A Rockett; Dominic P Kwiatkowski; Octavio Fernandes
Journal:  PLoS One       Date:  2012-05-16       Impact factor: 3.240

7.  High Level of Specific Anti-Plasmodium Falciparum Merozoite IgG1 Antibodies in Rural Asymptomatic Individuals of Dienga, South-Eastern Gabon.

Authors:  Irène Pegha-Moukandja; Roméo-Karl Imboumy-Limoukou; Nina Tchitoula-Makaya; Augustin-Ghislain Mouinga-Ondeme; Jean Claude Biteghe-Bi-Essone; Dieudonne Nkoghe Mba; Jean-Bernard Lekana-Douki; Fousseyni S Toure Ndouo
Journal:  Eur J Microbiol Immunol (Bp)       Date:  2017-12-04
  7 in total

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