Literature DB >> 15796677

The primacy of cognition in schizophrenia.

R Walter Heinrichs1.   

Abstract

Cognitive tasks and concepts are used increasingly in schizophrenia science and treatment. Recent meta-analyses show that across a spectrum of research domains only cognitive measures distinguish a majority of schizophrenia patients from healthy people. Average effect sizes derived from common clinical tests of attention, memory, language, and reasoning are twice as large as those obtained in structural magnetic resonance imaging and positron emission tomography studies. Chronic stress, genes, brain disturbances, task structure, gender, and sociocultural background may all enhance the sensitivity of cognitive performance to schizophrenia. At the same time, disease heterogeneity and the presence of endophenotypes and subtypes within the patient population may place upper limits on the strength of any specific cognitive finding. Schizophrenia is a complex biobehavioral disorder that manifests itself primarily in cognition. 2005 APA, all rights reserved

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Year:  2005        PMID： 15796677     DOI： 10.1037/0003-066X.60.3.229

Source DB:  PubMed          Journal:  Am Psychol        ISSN： 0003-066X


  96 in total

1.  Premorbid multivariate markers of neurodevelopmental instability in the prediction of adult schizophrenia-spectrum disorder: a high-risk prospective investigation.

Authors:  Shana Golembo-Smith; Jason Schiffman; Emily Kline; Holger J Sørensen; Erik L Mortensen; Laura Stapleton; Kentaro Hayashi; Niels M Michelsen; Morten Ekstrøm; Sarnoff Mednick
Journal:  Schizophr Res       Date:  2012-06-02       Impact factor: 4.939

2.  Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine.

Authors:  Kathleen S Alexander; Hui-Qiu Wu; Robert Schwarcz; John P Bruno
Journal:  Psychopharmacology (Berl)       Date:  2011-10-26       Impact factor: 4.530

Review 3.  Mistreating Psychology in the Decades of the Brain.

Authors:  Gregory A Miller
Journal:  Perspect Psychol Sci       Date:  2010-11

4.  Neurocognitive impairment in middle-aged and older adults with bipolar disorder: comparison to schizophrenia and normal comparison subjects.

Authors:  Colin A Depp; David J Moore; David Sitzer; Barton W Palmer; Lisa T Eyler; Scott Roesch; Barry D Lebowitz; Dilip V Jeste
Journal:  J Affect Disord       Date:  2007-01-16       Impact factor: 4.839

5.  Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia (COGS).

Authors:  William S Stone; Anthony J Giuliano; Ming T Tsuang; David L Braff; Kristin S Cadenhead; Monica E Calkins; Dorcas J Dobie; Stephen V Faraone; Robert Freedman; Michael F Green; Tiffany A Greenwood; Raquel E Gur; Ruben C Gur; Gregory A Light; Jim Mintz; Keith H Nuechterlein; Ann Olincy; Allen D Radant; Andrea H Roe; Nicholas J Schork; Larry J Siever; Jeremy M Silverman; Neal R Swerdlow; Alison R Thomas; Debby W Tsuang; Bruce I Turetsky; Larry J Seidman
Journal:  Schizophr Res       Date:  2011-02-01       Impact factor: 4.939

6.  Empirically defined patterns of executive function deficits in schizophrenia and their relation to everyday functioning: a person-centered approach.

Authors:  Mary Iampietro; Tania Giovannetti; Deborah A G Drabick; Rachel K Kessler
Journal:  Clin Neuropsychol       Date:  2012-10-04       Impact factor: 3.535

7.  Multivariate Relationships Between Cognition and Brain Anatomy Across the Psychosis Spectrum.

Authors:  Amanda L Rodrigue; Jennifer E McDowell; Neeraj Tandon; Matcheri S Keshavan; Carol A Tamminga; Godfrey D Pearlson; John A Sweeney; Robert D Gibbons; Brett A Clementz
Journal:  Biol Psychiatry Cogn Neurosci Neuroimaging       Date:  2018-03-31

8.  California Verbal Learning Test-II performance in schizophrenia as a function of ascertainment strategy: comparing the first and second phases of the Consortium on the Genetics of Schizophrenia (COGS).

Authors:  William S Stone; Raquelle I Mesholam-Gately; David L Braff; Monica E Calkins; Robert Freedman; Michael F Green; Tiffany A Greenwood; Raquel E Gur; Ruben C Gur; Laura C Lazzeroni; Gregory A Light; Keith H Nuechterlein; Ann Olincy; Allen D Radant; Larry J Siever; Jeremy M Silverman; Joyce Sprock; Catherine A Sugar; Neal R Swerdlow; Debby W Tsuang; Ming T Tsuang; Bruce I Turetsky; Larry J Seidman
Journal:  Schizophr Res       Date:  2014-12-12       Impact factor: 4.939

9.  Neurocognitive profiles in the prodrome to psychosis in NAPLS-1.

Authors:  Eva Velthorst; Eric C Meyer; Anthony J Giuliano; Jean Addington; Kristin S Cadenhead; Tyrone D Cannon; Barbara A Cornblatt; Thomas H McGlashan; Diana O Perkins; Ming T Tsuang; Elaine F Walker; Scott W Woods; Carrie E Bearden; Larry J Seidman
Journal:  Schizophr Res       Date:  2018-08-02       Impact factor: 4.939

10.  A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry.

Authors:  Jana Strohmaier; Josef Frank; Jens R Wendland; Johannes Schumacher; Rami Abou Jamra; Jens Treutlein; Vanessa Nieratschker; René Breuer; Manuel Mattheisen; Stefan Herms; Thomas W Mühleisen; Wolfgang Maier; Markus M Nöthen; Sven Cichon; Marcella Rietschel; Thomas G Schulze
Journal:  Schizophr Res       Date:  2010-01-18       Impact factor: 4.939
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