Literature DB >> 15794920

The role of HNF4A variants in the risk of type 2 diabetes.

Karen L Mohlke1, Michael Boehnke.   

Abstract

Genes influence susceptibility to type 2 diabetes mellitus (T2DM), and both positional cloning and candidate gene approaches have been used to identify these genes. Linkage analysis has generated evidence for T2DM-predisposing variants on chromosome 20q in studies of Caucasians, Asians, and Africans, and fine-mapping recently identified a likely susceptibility gene, hepatocyte nuclear factor 4-alpha (HNF4A). Rare loss-of-function mutations in HNF4A cause maturity-onset diabetes of the young and now common noncoding variants have been found to be associated with T2DM.

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Year:  2005        PMID： 15794920     DOI： 10.1007/s11892-005-0043-y

Source DB:  PubMed          Journal:  Curr Diab Rep        ISSN： 1534-4827            Impact factor:   4.810


  68 in total

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Journal:  Nat Genet       Date:  2000-10       Impact factor: 38.330

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  14 in total

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8.  Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist.

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Review 9.  Insights on pathogenesis of type 2 diabetes from MODY genetics.

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Journal:  Curr Diab Rep       Date:  2007-04       Impact factor: 5.430

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