Literature DB >> 15794919

Nonobese diabetic mice and the genetics of diabetes susceptibility.

Edward H Leiter1.   

Abstract

The nonobese diabetic mouse spontaneously develops an autoimmune, T-cell-mediated type 1 diabetes (T1D). Common and rare alleles both within a diabetogenic major histocompatibility complex (MHC) and multiple non-MHC genes combine to impair normal communication between the innate and acquired immune system, leading to loss of immune tolerance. An understanding of how variable collections of genes interact with each other and with environmental cues offers important insights as to the complexities of T1D inheritance in humans.

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Year:  2005        PMID： 15794919     DOI： 10.1007/s11892-005-0042-z

Source DB:  PubMed          Journal:  Curr Diab Rep        ISSN： 1534-4827            Impact factor:   4.810


  49 in total

1.  Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin.

Authors:  D V Serreze; M Bridgett; H D Chapman; E Chen; S D Richard; E H Leiter
Journal:  J Immunol       Date:  1998-02-01       Impact factor: 5.422

2.  Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis.

Authors:  C J Fox; A D Paterson; S M Mortin-Toth; J S Danska
Journal:  Am J Hum Genet       Date:  2000-06-09       Impact factor: 11.025

3.  Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse.

Authors:  P A Lyons; N Armitage; C J Lord; M S Phillips; J A Todd; L B Peterson; L S Wicker
Journal:  Diabetes       Date:  2001-11       Impact factor: 9.461

4.  Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9.2.

Authors:  T Siegmund; N Armitage; L S Wicker; L B Peterson; J A Todd; P A Lyons
Journal:  Diabetes       Date:  2000-09       Impact factor: 9.461

5.  Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.

Authors:  B Wang; I André; A Gonzalez; J D Katz; M Aguet; C Benoist; D Mathis
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

6.  Polygenic control of autoimmune diabetes in nonobese diabetic mice.

Authors:  S Ghosh; S M Palmer; N R Rodrigues; H J Cordell; C M Hearne; R J Cornall; J B Prins; P McShane; G M Lathrop; L B Peterson
Journal:  Nat Genet       Date:  1993-08       Impact factor: 38.330

7.  Prevention of type 1 diabetes by gene therapy.

Authors:  Chaorui Tian; Jessamyn Bagley; Nathalie Cretin; Nilufer Seth; Kai W Wucherpfennig; John Iacomini
Journal:  J Clin Invest       Date:  2004-10       Impact factor: 14.808

8.  Genetic analysis of diabetes and insulitis in an interspecific cross of the nonobese diabetic mouse with Mus spretus.

Authors:  B de Gouyon; E Melanitou; M F Richard; M Requarth; I H Hahn; J L Guenet; F Demenais; C Julier; G M Lathrop; C Boitard
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

9.  MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice.

Authors:  David V Serreze; T Matthew Holl; Michele P Marron; Robert T Graser; Ellis A Johnson; Caroline Choisy-Rossi; Robyn M Slattery; Scott M Lieberman; Teresa P DiLorenzo
Journal:  J Immunol       Date:  2004-01-15       Impact factor: 5.422

10.  A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus.

Authors:  P Concannon; K J Gogolin-Ewens; D A Hinds; B Wapelhorst; V A Morrison; B Stirling; M Mitra; J Farmer; S R Williams; N J Cox; G I Bell; N Risch; R S Spielman
Journal:  Nat Genet       Date:  1998-07       Impact factor: 38.330
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  13 in total

Review 1.  Type 1 diabetes in mice and men: gene expression profiling to investigate disease pathogenesis.

Authors:  Linda Yip; C Garrison Fathman
Journal:  Immunol Res       Date:  2014-05       Impact factor: 2.829

2.  Establishment of "The Gene Mine": a resource for rapid identification of complex trait genes.

Authors:  Grant Morahan; Lois Balmer; Donald Monley
Journal:  Mamm Genome       Date:  2008-08-21       Impact factor: 2.957

Review 3.  Genetic analysis of type 1 diabetes: embryonic stem cells as new tools to unlock biological mechanisms in type 1 diabetes.

Authors:  Nick Holmes; Anne Cooke
Journal:  Rev Diabet Stud       Date:  2012-12-28

4.  2α-Methyl-19-nor-(20S)-1,25-dihydroxyvitamin D(3) protects the insulin 2 knockout non-obese diabetic mouse from developing type 1 diabetes without hypercalcaemia.

Authors:  C M Kiekhaefer; B Weber; M Huggins; C Gorichanaz; J A Nehring; H F DeLuca
Journal:  Clin Exp Immunol       Date:  2011-12       Impact factor: 4.330

Review 5.  Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.

Authors:  John P Driver; David V Serreze; Yi-Guang Chen
Journal:  Semin Immunopathol       Date:  2010-04-28       Impact factor: 9.623

6.  Over-expression of Stat5b confers protection against diabetes in the non-obese diabetic (NOD) mice via up-regulation of CD4(+)CD25(+) regulatory T cells.

Authors:  Yulan Jin; Sharad Purohit; Xueqin Chen; Bing Yi; Jin-Xiong She
Journal:  Biochem Biophys Res Commun       Date:  2012-07-10       Impact factor: 3.575

7.  Transfusion of nonobese diabetic mice with allogeneic newborn blood ameliorates autoimmune diabetes and modifies the expression of selected immune response genes.

Authors:  Sundararajan Jayaraman; Tejas Patel; Vasu Patel; Shahnaz Ajani; Rebecca Garza; Arathi Jayaraman; Sung Kwon; Rajvir Singh; Damiano Rondelli; Bellur S Prabhakar; Mark Holterman
Journal:  J Immunol       Date:  2010-02-17       Impact factor: 5.422

8.  Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

Authors:  Manabu Araki; Denise Chung; Sue Liu; Daniel B Rainbow; Giselle Chamberlain; Valerie Garner; Kara M D Hunter; Lalitha Vijayakrishnan; Laurence B Peterson; Mohamed Oukka; Arlene H Sharpe; Raymond Sobel; Vijay K Kuchroo; Linda S Wicker
Journal:  J Immunol       Date:  2009-09-25       Impact factor: 5.422

9.  Development of standardized insulin treatment protocols for spontaneous rodent models of type 1 diabetes.

Authors:  Christian W Grant; Shane K Duclos; Catherine M Moran-Paul; Barak Yahalom; Rebecca S Tirabassi; Guillermo Arreaza-Rubin; Lisa M Spain; Dennis L Guberski
Journal:  Comp Med       Date:  2012-10       Impact factor: 0.982

10.  Molecular phenotyping of immune cells from young NOD mice reveals abnormal metabolic pathways in the early induction phase of autoimmune diabetes.

Authors:  Jian Wu; Dorothy N Kakoola; Nataliya I Lenchik; Dominic M Desiderio; Dana R Marshall; Ivan C Gerling
Journal:  PLoS One       Date:  2012-10-11       Impact factor: 3.240
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