Literature DB >> 15794918

Adiponectin: an adipokine linking adipocytes and type 2 diabetes in humans.

Kazuo Hara1, Toshimasa Yamauchi, Takashi Kadowaki.   

Abstract

Adipocyte-derived adiponectin is an insulin-sensitizing and antiatherosclerotic hormone, and replenishment of adiponectin in animal models ameliorated insulin resistance and atherosclerosis. In humans, recent studies have demonstrated that adiponectin level is a good predictor of developing type 2 diabetes and coronary artery disease. Decreasing level of adiponectin is caused by the interaction between genetic factors, such as single nucleotide polymorphisms in the adiponectin gene, and environmental factors, such as high-fat diet. Agents that increase blood level of adiponectin or enhance the actions of adiponectin can be an ideal medicine for ameliorating insulin resistance and type 2 diabetes.

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Year:  2005        PMID： 15794918     DOI： 10.1007/s11892-005-0041-0

Source DB:  PubMed          Journal:  Curr Diab Rep        ISSN： 1534-4827            Impact factor:   4.810


  34 in total

1.  Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.

Authors:  A H Kissebah; G E Sonnenberg; J Myklebust; M Goldstein; K Broman; R G James; J A Marks; G R Krakower; H J Jacob; J Weber; L Martin; J Blangero; A G Comuzzie
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

2.  The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome.

Authors:  A G Comuzzie; T Funahashi; G Sonnenberg; L J Martin; H J Jacob; A E Black; D Maas; M Takahashi; S Kihara; S Tanaka; Y Matsuzawa; J Blangero; D Cohen; A Kissebah
Journal:  J Clin Endocrinol Metab       Date:  2001-09       Impact factor: 5.958

3.  Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial.

Authors:  Katherine Esposito; Alessandro Pontillo; Carmen Di Palo; Giovanni Giugliano; Mariangela Masella; Raffaele Marfella; Dario Giugliano
Journal:  JAMA       Date:  2003-04-09       Impact factor: 56.272

4.  Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.

Authors:  Y Arita; S Kihara; N Ouchi; M Takahashi; K Maeda; J Miyagawa; K Hotta; I Shimomura; T Nakamura; K Miyaoka; H Kuriyama; M Nishida; S Yamashita; K Okubo; K Matsubara; M Muraguchi; Y Ohmoto; T Funahashi; Y Matsuzawa
Journal:  Biochem Biophys Res Commun       Date:  1999-04-02       Impact factor: 3.575

5.  Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.

Authors:  S Jacob; J Machann; K Rett; K Brechtel; A Volk; W Renn; E Maerker; S Matthaei; F Schick; C D Claussen; H U Häring
Journal:  Diabetes       Date:  1999-05       Impact factor: 9.461

6.  Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys.

Authors:  K Hotta; T Funahashi; N L Bodkin; H K Ortmeyer; Y Arita; B C Hansen; Y Matsuzawa
Journal:  Diabetes       Date:  2001-05       Impact factor: 9.461

7.  Adiponectin and protection against type 2 diabetes mellitus.

Authors:  Joachim Spranger; Anja Kroke; Matthias Möhlig; Manuela M Bergmann; Michael Ristow; Heiner Boeing; Andreas F H Pfeiffer
Journal:  Lancet       Date:  2003-01-18       Impact factor: 79.321

8.  Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes.

Authors:  Julia Tonelli; Weijie Li; Preeti Kishore; Utpal B Pajvani; Elize Kwon; Charles Weaver; Philipp E Scherer; Meredith Hawkins
Journal:  Diabetes       Date:  2004-06       Impact factor: 9.461

9.  Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis.

Authors:  Toshimasa Yamauchi; Junji Kamon; Hironori Waki; Yasushi Imai; Nobuhiro Shimozawa; Kyouji Hioki; Shoko Uchida; Yusuke Ito; Keisuke Takakuwa; Junji Matsui; Makoto Takata; Kazuhiro Eto; Yasuo Terauchi; Kajuro Komeda; Masaki Tsunoda; Koji Murakami; Yasuyuki Ohnishi; Takeshi Naitoh; Kenichi Yamamura; Yoshito Ueyama; Philippe Froguel; Satoshi Kimura; Ryozo Nagai; Takashi Kadowaki
Journal:  J Biol Chem       Date:  2002-11-12       Impact factor: 5.157

10.  Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.

Authors:  Hironori Waki; Toshimasa Yamauchi; Junji Kamon; Yusuke Ito; Shoko Uchida; Shunbun Kita; Kazuo Hara; Yusuke Hada; Francis Vasseur; Philippe Froguel; Satoshi Kimura; Ryozo Nagai; Takashi Kadowaki
Journal:  J Biol Chem       Date:  2003-07-23       Impact factor: 5.157
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  10 in total

Review 1.  The role of adiponectin in reproduction: from polycystic ovary syndrome to assisted reproduction.

Authors:  Konstantinos G Michalakis; James H Segars
Journal:  Fertil Steril       Date:  2010-06-19       Impact factor: 7.329

Review 2.  Genetic background in nonalcoholic fatty liver disease: A comprehensive review.

Authors:  Fabio Salvatore Macaluso; Marcello Maida; Salvatore Petta
Journal:  World J Gastroenterol       Date:  2015-10-21       Impact factor: 5.742

3.  Adiponectin and leptin gene polymorphisms in women with gestational diabetes mellitus.

Authors:  Andrzej Pawlik; Joanna Teler; Agnieszka Maciejewska; Marek Sawczuk; Krzysztof Safranow; Violetta Dziedziejko
Journal:  J Assist Reprod Genet       Date:  2017-01-03       Impact factor: 3.412

4.  Influence of adiponectin gene polymorphisms in Japanese patients with non-alcoholic fatty liver disease.

Authors:  Katsutoshi Tokushige; Etsuko Hashimoto; Haruka Noto; Satoru Yatsuji; Makiko Taniai; Nobuyuki Torii; Keiko Shiratori
Journal:  J Gastroenterol       Date:  2009-05-30       Impact factor: 7.527

5.  The inflammatory changes of adipose tissue in late pregnant mice.

Authors:  Lingyun Zhang; Takashi Sugiyama; Nao Murabayashi; Takashi Umekawa; Ning Ma; Yuki Kamimoto; Yoshihiro Ogawa; Norimasa Sagawa
Journal:  J Mol Endocrinol       Date:  2011-08-30       Impact factor: 5.098

6.  Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes.

Authors:  Lucia Berti; Martin Irmler; Marty Zdichavsky; Tobias Meile; Anja Böhm; Norbert Stefan; Andreas Fritsche; Johannes Beckers; Alfred Königsrainer; Hans-Ulrich Häring; Martin Hrabě de Angelis; Harald Staiger
Journal:  Mol Metab       Date:  2015-05-01       Impact factor: 7.422

7.  Short and long-term impact of lipectomy on expression profile of hepatic anabolic genes in rats: a high fat and high cholesterol diet-induced obese model.

Authors:  Bey-Leei Ling; Chun-Tang Chiu; Hsiu-Chin Lu; Jin-Jin Lin; Chiung-Yin Kuo; Fen-Pi Chou
Journal:  PLoS One       Date:  2014-09-29       Impact factor: 3.240

8.  T2D-Db: an integrated platform to study the molecular basis of Type 2 diabetes.

Authors:  Shipra Agrawal; Nevenka Dimitrova; Prasanthi Nathan; K Udayakumar; S Sai Lakshmi; S Sriram; N Manjusha; Urmi Sengupta
Journal:  BMC Genomics       Date:  2008-07-07       Impact factor: 3.969

9.  Paradoxically Low Levels of Total and HMW Adiponectin in Relation to Metabolic Parameters in a Tongan Population.

Authors:  Philip Peake; Stephen Colagiuri; Lesley V Campbell; Yvonne Shen
Journal:  ISRN Endocrinol       Date:  2013-07-09

Review 10.  Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases.

Authors:  Jessica Tozour; Francine Hughes; Arnaud Carrier; Didier Vieau; Fabien Delahaye
Journal:  Biomolecules       Date:  2020-09-23
  10 in total

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