Literature DB >> 15794338

Synthesis and antibacterial activity of adamantyl substituted pyrimidines.

Barbara Orzeszko1, Agnieszka Ewa Laudy, Bohdan Jerzy Starościak, Andrzej Orzeszko, Zygmunt Kazimierczuk.   

Abstract

A series of new S-substituted 6-adamantylpyrimidines were prepared by alkylation on the thiol groups in 6-adamant-1-yl-2-methyl-3H-pyrimidine-4-thione and 6-adamant-1-yl-2-thioxo-2,3-dihydro-1H-pirymidin-4-one, respectively. Then, these compounds were tested against several bacterial strains as well as fungi.

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Year:  2004        PMID: 15794338

Source DB:  PubMed          Journal:  Acta Pol Pharm        ISSN: 0001-6837            Impact factor:   0.330


  1 in total

Review 1.  Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors.

Authors:  Agnieszka Wróbel; Karolina Arciszewska; Dawid Maliszewski; Danuta Drozdowska
Journal:  J Antibiot (Tokyo)       Date:  2019-10-02       Impact factor: 2.649

  1 in total

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