Literature DB >> 15793577

The subthalamic nucleus exerts opposite control on cocaine and 'natural' rewards.

Christelle Baunez1, Carine Dias, Martine Cador, Marianne Amalric.   

Abstract

A challenge in treating drug addicts is preventing their pathological motivation for the drug without impairing their general affective state toward natural reinforcers. Here we have shown that discrete lesions of the subthalamic nucleus greatly decreased the motivation of rats for cocaine while increasing it for food reward. The subthalamic nucleus, a key structure controlling basal ganglia outputs, is therefore able to oppositely modulate the effect of 'natural' rewards and drugs of abuse on behavior. Modulating the activity of the subthalamic nucleus might prove to be a new target for the treatment of cocaine addiction.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15793577     DOI： 10.1038/nn1429

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  67 in total

Review 1.  The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors.

Authors:  David H Root; Roberto I Melendez; Laszlo Zaborszky; T Celeste Napier
Journal:  Prog Neurobiol       Date:  2015-04-06       Impact factor: 11.685

Review 2.  The ventral pallidum and relapse in alcohol seeking.

Authors:  Asheeta A Prasad; Gavan P McNally
Journal:  Br J Pharmacol       Date:  2020-07-09       Impact factor: 8.739

Review 3.  Neuromodulation interventions for addictive disorders: challenges, promise, and roadmap for future research.

Authors:  Primavera A Spagnolo; David Goldman
Journal:  Brain       Date:  2017-05-01       Impact factor: 13.501

4.  Silent plateau potentials, rhythmic bursts, and pacemaker firing: three patterns of activity that coexist in quadristable subthalamic neurons.

Authors:  Jason I Kass; Isabelle M Mintz
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-22       Impact factor: 11.205

5.  Spontaneous sleep modulates the firing pattern of parkinsonian subthalamic nucleus.

Authors:  Alessandro Stefani; Salvatore Galati; Antonella Peppe; Andrea Bassi; Mariangela Pierantozzi; Atticus H Hainsworth; Giorgio Bernardi; Antonio Orlacchio; Paolo Stanzione; Paolo Mazzone
Journal:  Exp Brain Res       Date:  2005-11-18       Impact factor: 1.972

Review 6.  Deep brain stimulation for the treatment of addiction: basic and clinical studies and potential mechanisms of action.

Authors:  R Christopher Pierce; Fair M Vassoler
Journal:  Psychopharmacology (Berl)       Date:  2013-08-02       Impact factor: 4.530

Review 7.  Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference.

Authors:  Vincent B McGinty; Benjamin Y Hayden; Sarah R Heilbronner; Eric C Dumont; Steven M Graves; Martine M Mirrione; Johann du Hoffmann; Gregory C Sartor; Rodrigo A España; E Zayra Millan; Alexandra G Difeliceantonio; Nathan J Marchant; T Celeste Napier; David H Root; Stephanie L Borgland; Michael T Treadway; Stan B Floresco; Jacqueline F McGinty; Suzanne Haber
Journal:  Behav Brain Res       Date:  2011-07-26       Impact factor: 3.332

8.  Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use.

Authors:  Yann Pelloux; Mickaël Degoulet; Alix Tiran-Cappello; Candie Cohen; Sylvie Lardeux; Olivier George; George F Koob; Serge H Ahmed; Christelle Baunez
Journal:  Mol Psychiatry       Date:  2018-06-07       Impact factor: 15.992

Review 9.  The role of the subthalamic nucleus in cognition.

Authors:  David B Weintraub; Kareem A Zaghloul
Journal:  Rev Neurosci       Date:  2013       Impact factor: 4.353

10.  Impact of medial orbital cortex and medial subthalamic nucleus inactivation, individually and together, on the maintenance of cocaine self-administration behavior in rats.

Authors:  K M Kantak; L M Yager; M F Brisotti
Journal:  Behav Brain Res       Date:  2012-10-22       Impact factor: 3.332
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.