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Literature DB >> 15793156

Role of P-glycoprotein in distribution of nelfinavir across the blood-mammary tissue barrier and blood-brain barrier.

Jeffrey E Edwards¹, Jane Alcorn, Juoko Savolainen, Bradley D Anderson, Patrick J McNamara.

Abstract

As a first approach in understanding the possible efficacy and toxicity of human immunodeficiency virus protease inhibitors during breast feeding, the milk-to-plasma ratio of nelfinavir was determined in lactating rats. The milk-to-plasma ratio of nelfinavir was determined to be 0.56 +/- 0.10 (means +/- standard deviations). Western blotting indicated that P-glycoprotein is expressed in rat mammary and brain tissue; however, the multidrug-resistant modulator GF120918 showed a significant effect only at the blood-brain barrier and not at the mammary-epithelial tissue barrier.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2005 PMID： 15793156 PMCID： PMC1068594 DOI： 10.1128/AAC.49.4.1626-1628.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

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9 in total

1. N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide (GF120918) as a chemical ATP-binding cassette transporter family G member 2 (Abcg2) knockout model to study nitrofurantoin transfer into milk.

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Journal: Mol Imaging Biol Date: 2016-12 Impact factor: 3.488

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Journal: Br J Clin Pharmacol Date: 2013-12 Impact factor: 4.335