Literature DB >> 15793143

Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase.

Mary Bakhanashvili1, Elena Novitsky, Ethan Rubinstein, Itzchak Levy, Galia Rahav.   

Abstract

We investigated the ability of p53 in cytoplasm to excise nucleoside analogs (NAs). A decrease in incorporation of NAs by human immunodeficiency virus type 1 reverse transcriptase and their excision from DNA by p53, provided by the cytoplasmic fraction of LCC2 cells, suggest that p53 in cytoplasm may act as an external proofreader for NA incorporation.

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Year:  2005        PMID： 15793143      PMCID： PMC1068624          DOI： 10.1128/AAC.49.4.1576-1579.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Exonucleolytic proofreading by p53 protein.

Authors:  M Bakhanashvili
Journal:  Eur J Biochem       Date:  2001-04

2.  Role of p53 in cellular response to anticancer nucleoside analog-induced DNA damage.

Authors:  L Feng; G Achanta; H Pelicano; W Zhang; W Plunkett; P Huang
Journal:  Int J Mol Med       Date:  2000-06       Impact factor: 4.101

3.  Action of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on DNA metabolism: incorporation, excision, and cellular response.

Authors:  Yan Zhou; Geetha Achanta; Helene Pelicano; Varsha Gandhi; William Plunkett; Peng Huang
Journal:  Mol Pharmacol       Date:  2002-01       Impact factor: 4.436

4.  p53 enhances the fidelity of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase.

Authors:  M Bakhanashvili
Journal:  Oncogene       Date:  2001-11-15       Impact factor: 9.867

5.  Genetic variation in AIDS viruses.

Authors:  J M Coffin
Journal:  Cell       Date:  1986-07-04       Impact factor: 41.582

6.  The accuracy of reverse transcriptase from HIV-1.

Authors:  J D Roberts; K Bebenek; T A Kunkel
Journal:  Science       Date:  1988-11-25       Impact factor: 47.728

7.  Fidelity of the RNA-dependent DNA synthesis exhibited by the reverse transcriptases of human immunodeficiency virus types 1 and 2 and of murine leukemia virus: mispair extension frequencies.

Authors:  M Bakhanashvili; A Hizi
Journal:  Biochemistry       Date:  1992-10-06       Impact factor: 3.162

8.  Fidelity of HIV-1 reverse transcriptase copying RNA in vitro.

Authors:  J P Ji; L A Loeb
Journal:  Biochemistry       Date:  1992-02-04       Impact factor: 3.162

9.  Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein.

Authors:  P Huang
Journal:  Oncogene       Date:  1998-07-23       Impact factor: 9.867

10.  P53 in cytoplasm may enhance the accuracy of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase.

Authors:  Mary Bakhanashvili; Elena Novitsky; Gila Lilling; Gilia Rahav
Journal:  Oncogene       Date:  2004-09-09       Impact factor: 9.867
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  2 in total

1.  Exonucleolytic degradation of RNA by p53 protein in cytoplasm.

Authors:  Mary Bakhanashvili; Rachel Gedelovich; Shai Grinberg; Galia Rahav
Journal:  J Mol Med (Berl)       Date:  2007-08-15       Impact factor: 4.599

2.  Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53.

Authors:  Tuck Seng Wong; Sridharan Rajagopalan; Fiona M Townsley; Stefan M Freund; Miriana Petrovich; David Loakes; Alan R Fersht
Journal:  Nucleic Acids Res       Date:  2008-12-09       Impact factor: 16.971
  2 in total

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