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Literature DB >> 15793140

Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate.

Mariagrazia Perilli¹, Claudia Mugnaioli, Francesco Luzzaro, Marianna Fiore, Stefania Stefani, Gian Maria Rossolini, Gianfranco Amicosante.

Abstract

A new natural TEM derivative with extended-spectrum beta-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The bla(TEM-134) gene was not transferable by conjugation and, apparently, was chromosomally encoded. Expression studies with Escherichia coli revealed efficient cefotaximase and ceftazidimase activity for TEM-134.

Entities: Chemical Mutation Species

Mesh：

Substances：

Year: 2005 PMID： 15793140 PMCID： PMC1068604 DOI： 10.1128/AAC.49.4.1564-1566.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

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Authors: Laura Pagani; Elisabetta Mantengoli; Roberta Migliavacca; Elisabetta Nucleo; Simona Pollini; Melissa Spalla; Rossana Daturi; Egidio Romero; Gian Maria Rossolini
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