Literature DB >> 1579255

Clinical utility of unbound antiepileptic drug blood levels in the management of epilepsy.

N J Lenn1, M Robertson.   

Abstract

We tabulated all unbound and total antiepileptic blood levels collected in 13 months. According to strict criteria, 24% of phenytoin and 15% of valproate unbound blood levels but none of the carbamazepine unbound levels had clinical significance in the management of seizures or side effects. These data support frequent use of unbound phenytoin or valproate blood levels in the management of epilepsy.

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Year:  1992        PMID： 1579255     DOI： 10.1212/wnl.42.5.988

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  4 in total

1.  Anticonvulsant use in elderly patients in long-term care units.

Authors:  S Timmons; F McCarthy; J Duggan; C Twomey
Journal:  Ir J Med Sci       Date:  2003 Apr-Jun       Impact factor: 1.568

Review 2.  Selected pharmacokinetic issues of the use of antiepileptic drugs and parenteral nutrition in critically ill patients.

Authors:  Muhannad R M Salih; Mohd Baidi Bahari; Arwa Y Abd
Journal:  Nutr J       Date:  2010-12-31       Impact factor: 3.271

3.  Sodium Valproate Incompatibility with Parenteral Nutrition Admixtures-A Risk to Patient Safety: An In Vitro Evaluation Study.

Authors:  Ludwika Piwowarczyk; Szymon Tomczak; Patryk Antkowiak; Anna Jelińska; Maciej Stawny
Journal:  Pharmaceutics       Date:  2022-02-07       Impact factor: 6.321

4.  Therapeutic drug monitoring of phenytoin and valproic acid in critically ill patients at Windhoek Central Hospital, Namibia.

Authors:  Bonifasius S Singu; Helen Morrison; Lydia Irengeya; Roger K Verbeeck
Journal:  Afr J Lab Med       Date:  2022-07-21
  4 in total

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