Literature DB >> 15792445

beta-Hematin (hemozoin) mediated decompostion of polyunsaturated fatty acids to 4-hydroxy-2-nonenal.

Crystal M Miller1, Clare Kenny Carney, Alexandra C Schrimpe, David W Wright.   

Abstract

beta-Hematin is an important heme metabolite of malarial infection. Its role as an agent mediating the formation of the reactive electrophile 4-hydroxynonenal (HNE) from polyunsaturated fatty acids was investigated. In vitro formation of HNE was found to be facilitated by the presence of hemozoin in a concentration-dependent fashion. The reactivity of HNE derived from reaction with beta-hematin was confirmed through its ability to form protein adducts on myoglobin.

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Year:  2005        PMID： 15792445     DOI： 10.1021/ic048821i

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  5 in total

1.  The basis of the immunomodulatory activity of malaria pigment (hemozoin).

Authors:  Clare K Carney; Alexandra C Schrimpe; Kristin Halfpenny; Reese S Harry; Crystal M Miller; Malgorzata Broncel; Sarah L Sewell; Jacob E Schaff; Ravinder Deol; Melissa D Carter; David W Wright
Journal:  J Biol Inorg Chem       Date:  2006-07-26       Impact factor: 3.358

Review 2.  Hemozoin: oil versus water.

Authors:  John M Pisciotta; David Sullivan
Journal:  Parasitol Int       Date:  2007-10-13       Impact factor: 2.230

3.  Identification of hydroxyeicosatetraenoic acid components of schistosomal hemozoin.

Authors:  Melissa D Carter; S Reese Harry; David W Wright
Journal:  Biochem Biophys Res Commun       Date:  2007-09-24       Impact factor: 3.575

4.  Comparative analysis of gene expression changes mediated by individual constituents of hemozoin.

Authors:  Alexandra C Schrimpe; David W Wright
Journal:  Chem Res Toxicol       Date:  2009-03-16       Impact factor: 3.739

Review 5.  Role of the lipoperoxidation product 4-hydroxynonenal in the pathogenesis of severe malaria anemia and malaria immunodepression.

Authors:  Evelin Schwarzer; Paolo Arese; Oleksii A Skorokhod
Journal:  Oxid Med Cell Longev       Date:  2015-04-19       Impact factor: 6.543
  5 in total

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