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Literature DB >> 1579162

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex.

Abstract

A multiprotein complex that specifically recognizes cellular origins of DNA replication has been identified and purified from the yeast Saccharomyces cerevisiae. We observe a strong correlation between origin function and origin recognition by this activity. Interestingly, specific DNA binding by the origin recognition complex is dependent upon the addition of ATP. We propose that the origin recognition complex acts as the initiator protein for S. cerevisiae origins of DNA replication.

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Year: 1992 PMID： 1579162 DOI： 10.1038/357128a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

503 in total

1. DNA replication in quiescent cell nuclei: regulation by the nuclear envelope and chromatin structure.

Authors: Z H Lu; H Xu; G H Leno
Journal: Mol Biol Cell Date: 1999-12 Impact factor: 4.138

2. Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins.

Authors: Y Ogawa; T Takahashi; H Masukata
Journal: Mol Cell Biol Date: 1999-10 Impact factor: 4.272

3. Context-dependent modulation of replication activity of Saccharomyces cerevisiae autonomously replicating sequences by transcription factors.

Authors: H Kohzaki; Y Ito; Y Murakami
Journal: Mol Cell Biol Date: 1999-11 Impact factor: 4.272

4. Functionally distinct, sequence-specific replicator and origin elements are required for Drosophila chorion gene amplification.

Authors: L Lu; H Zhang; J Tower
Journal: Genes Dev Date: 2001-01-15 Impact factor: 11.361

5. Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.

Authors: G Oshiro; J C Owens; Y Shellman; R A Sclafani; J J Li
Journal: Mol Cell Biol Date: 1999-07 Impact factor: 4.272

6. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase.

Authors: L Zou; B Stillman
Journal: Mol Cell Biol Date: 2000-05 Impact factor: 4.272

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex.

1. DNA replication in quiescent cell nuclei: regulation by the nuclear envelope and chromatin structure.

2. Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins.

3. Context-dependent modulation of replication activity of Saccharomyces cerevisiae autonomously replicating sequences by transcription factors.

4. Functionally distinct, sequence-specific replicator and origin elements are required for Drosophila chorion gene amplification.

5. Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.

6. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase.

7. Insights into DNA replication from the third domain of life.

8. Distinct phosphoisoforms of the Xenopus Mcm4 protein regulate the function of the Mcm complex.

9. DNA repair in a yeast origin of replication: contributions of photolyase and nucleotide excision repair.

10. E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila.