| Literature DB >> 15790492 |
Kristen R Schneider-Berlin1, Tonya D Bonilla, Thomas C Rowe.
Abstract
Dequalinium (DEQ), a drug with both antimicrobial and anticancer activity, induced the formation of petite (respiration-deficient) mutants in the yeast Saccharomyces cerevisiae. DEQ was found to be approximately 50-fold more potent than ethidium bromide (EB) at inducing petites. Analysis of the DEQ-induced petite mutants indicated a complete loss of mitochondrial DNA (<1 copy/cell). Prior to the loss of mtDNA, DEQ caused cleavage of the mtDNA into a population of fragments 30-40kbp in size suggesting that this drug causes petites by inducing a breakdown of mtDNA. The selective effect of DEQ on yeast mtDNA may underlie the antifungal activity of this chemotherapeutic agent.Entities:
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Year: 2005 PMID： 15790492 DOI： 10.1016/j.mrfmmm.2004.12.010
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433