Literature DB >> 15789561

Myxobacterial epothilones and tubulysins as promising anticancer agents.

Alexander Dömling1, Wolfgang Richter.   

Abstract

Tubulin-binding agents play a pivotal role in current cancer therapy and there are many efforts in pre-clinical and clinical development of known and novel cytotoxic agents ongoing. In this article a known class, epothilones, as well as a novel class, tubulysins, are presented.

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Year:  2005        PMID： 15789561     DOI： 10.1007/s11030-005-1542-0

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  7 in total

1.  Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties.

Authors:  F Sasse; H Steinmetz; J Heil; G Höfle; H Reichenbach
Journal:  J Antibiot (Tokyo)       Date:  2000-09       Impact factor: 2.649

2.  Design and total synthesis of a superior family of epothilone analogues, which eliminate xenograft tumors to a nonrelapsable state.

Authors:  Ting-Chao Chou; Huajin Dong; Alexey Rivkin; Fumihiko Yoshimura; Ana E Gabarda; Young Shin Cho; William P Tong; Samuel J Danishefsky
Journal:  Angew Chem Int Ed Engl       Date:  2003-10-13       Impact factor: 15.336

3.  Design, synthesis, and biological properties of highly potent epothilone B analogues.

Authors:  K C Nicolaou; Pradip K Sasmal; Gerasimos Rassias; Mali Venkat Reddy; Karl-Heinz Altmann; Markus Wartmann; Aurora O'Brate; Paraskevi Giannakakou
Journal:  Angew Chem Int Ed Engl       Date:  2003-08-04       Impact factor: 15.336

4.  Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria.

Authors:  Heinrich Steinmetz; Nicole Glaser; Eberhardt Herdtweck; Florenz Sasse; Hans Reichenbach; Gerhard Höfle
Journal:  Angew Chem Int Ed Engl       Date:  2004-09-20       Impact factor: 15.336

5.  Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties.

Authors:  K Gerth; N Bedorf; G Höfle; H Irschik; H Reichenbach
Journal:  J Antibiot (Tokyo)       Date:  1996-06       Impact factor: 2.649

6.  Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones.

Authors:  Alexey Rivkin; Fumihiko Yoshimura; Ana E Gabarda; Ting-Chao Chou; Huajin Dong; William P Tong; Samuel J Danishefsky
Journal:  J Am Chem Soc       Date:  2003-03-12       Impact factor: 15.419

Review 7.  Signal transduction pathways of taxanes-induced apoptosis.

Authors:  Valérie Ganansia-Leymarie; Pierre Bischoff; Jean-Pierre Bergerat; Vincent Holl
Journal:  Curr Med Chem Anticancer Agents       Date:  2003-07
  7 in total
  2 in total

1.  Chemotherapeutic evaluation of a synthetic tubulysin analogue-dendrimer conjugate in c26 tumor bearing mice.

Authors:  William C Floyd; Gopal K Datta; Shinichi Imamura; Heidi M Kieler-Ferguson; Katherine Jerger; Andrew W Patterson; Megan E Fox; Francis C Szoka; Jean M J Fréchet; Jonathan A Ellman
Journal:  ChemMedChem       Date:  2011-01-03       Impact factor: 3.466

2.  Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy.

Authors:  Jennifer Herrmann; Yasser A Elnakady; Romina M Wiedmann; Angelika Ullrich; Manfred Rohde; Uli Kazmaier; Angelika M Vollmar; Rolf Müller
Journal:  PLoS One       Date:  2012-05-17       Impact factor: 3.240
  2 in total

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