Literature DB >> 15789549

HPLC-coupled spectroscopic techniques (UV, MS, NMR) for the structure elucidation of phthalides in Ligusticum chuanxiong.

S Zschocke1, I Klaiber, R Bauer, B Vogler.   

Abstract

Ligusticum chuanxiong Hort., a plant that is frequently used in traditional Chinese medicine, has been studied using HPLC-coupled spectroscopic techniques such as HPLC-UV, HPLC-MS as well as HPLC-NMR. With the aid of these modern spectroscopic techniques, the main constituents, namely senkyunolide A, butylphthalide, neocnidilide and Z-ligustilide, have been characterized and identified. Phthalide dimers, present in smaller amounts, have been identified by HPLC-UV and HPLC-MS analysis and compared with reference compounds. Stereochemical features of some phthalide monomers have been determined by detailed spectroscopic studies for the first time.

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Year:  2005        PMID： 15789549     DOI： 10.1007/s11030-005-1305-y

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  7 in total

1.  STUDIES ON THE CONSTITUENTS OF UMBELLIFERAE PLANTS. VIII. DISTRIBUTION OF ALKYLPHTHALIDES IN UMBELLIFERAE PLANTS.

Authors:  H MITSUHASHI; T MURAMATSU; U NAGAI; T NAKANO; K UENO
Journal:  Chem Pharm Bull (Tokyo)       Date:  1963-10       Impact factor: 1.645

2.  Misuse of herbal remedies: the case of an outbreak of terminal renal failure in Belgium (Chinese herbs nephropathy)

Authors:  L J Vanherweghem
Journal:  J Altern Complement Med       Date:  1998       Impact factor: 2.579

3.  5-Lipoxygenase and cyclooxygenase inhibitory active constituents from Qianghuo (Notopterygium incisum).

Authors:  S Zschocke; M Lehner; R Bauer
Journal:  Planta Med       Date:  1997-06       Impact factor: 3.352

4.  [Constituents of Cnidium officinale Makino. Structure of senkyunolide and gas chromatography-mass spectrometory of the related phthalides (author's transl)].

Authors:  T Yamagishi; H Kaneshima
Journal:  Yakugaku Zasshi       Date:  1977-03       Impact factor: 0.302

5.  Phthalides in the essential oil from roots of Levisticum officinale.

Authors:  M J Gijbels; J J Scheffer; A Baerheim Svendsen
Journal:  Planta Med       Date:  1982-04       Impact factor: 3.352

6.  Characterization of phthalides in Ligusticum chuanxiong by liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometry.

Authors:  Xiaozhe Zhang; Hongbin Xiao; Qing Xu; Xiuling Li; Jianing Wang; Xinmiao Liang
Journal:  J Chromatogr Sci       Date:  2003-09       Impact factor: 1.618

7.  Simultaneous analysis of seventeen chemical ingredients of Ligusticum chuanxiong by on-line high performance liquid chromatography-diode array detector-mass spectrometry.

Authors:  Song-Lin Li; Sunny Sun-Kin Chan; Ge Lin; Lei Ling; Ru Yan; Hoi-Sing Chung; Yun-Kau Tam
Journal:  Planta Med       Date:  2003-05       Impact factor: 3.352
  7 in total
  5 in total

1.  Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.

Authors:  Shixin Deng; Shao-Nong Chen; Ping Yao; Dejan Nikolic; Richard B van Breemen; Judy L Bolton; Harry H S Fong; Norman R Farnsworth; Guido F Pauli
Journal:  J Nat Prod       Date:  2006-04       Impact factor: 4.050

2.  Isolation and characterization of steroids, phthalide and essential oil of the fruits of Kelussia odoratissima Mozaff., an endemic mountain celery.

Authors:  S E Sajjadi; Y Shokoohinia; P Mehramiri
Journal:  Res Pharm Sci       Date:  2013-01

3.  A historical overview of natural products in drug discovery.

Authors:  Daniel A Dias; Sylvia Urban; Ute Roessner
Journal:  Metabolites       Date:  2012-04-16

Review 4.  Advances in the chemical analysis and biological activities of chuanxiong.

Authors:  Weixia Li; Yuping Tang; Yanyan Chen; Jin-Ao Duan
Journal:  Molecules       Date:  2012-09-06       Impact factor: 4.411

5.  Structural characterization and identification of major constituents in Jitai tablets by high-performance liquid chromatography/diode-array detection coupled with electrospray ionization tandem mass spectrometry.

Authors:  Shuping Wang; Lei Liu; Lingling Wang; Yaohua Hu; Weidong Zhang; Runhui Liu
Journal:  Molecules       Date:  2012-09-03       Impact factor: 4.411
  5 in total

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