Literature DB >> 15787494

Synthesis of epothilones via a silicon-tethered RCM reaction.

Tanja Gaich1, Johann Mulzer.   

Abstract

[reaction: see text] A short synthesis of epothilone B and D is reported. The key step for generating the C12-13-trisubstituted Z-double bond uses a ring-closing metathesis reaction of a disiloxane to form a nine-membered silicon-tethered ring.

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Year:  2005        PMID： 15787494     DOI： 10.1021/ol0500923

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Total synthesis of peloruside A through kinetic lactonization and relay ring-closing metathesis cyclization reactions.

Authors:  Thomas R Hoye; Junha Jeon; Lucas C Kopel; Troy D Ryba; Manomi A Tennakoon; Yini Wang
Journal:  Angew Chem Int Ed Engl       Date:  2010-08-16       Impact factor: 15.336

2.  An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis.

Authors:  Christopher Cordier; Daniel Morton; Stuart Leach; Thomas Woodhall; Catherine O'Leary-Steele; Stuart Warriner; Adam Nelson
Journal:  Org Biomol Chem       Date:  2008-04-10       Impact factor: 3.876
  2 in total

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