Literature DB >> 15787461

Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua.

Anthony D Wright1, Olaf Papendorf, Gabriele M König.   

Abstract

The new natural products 3,5-bis(2,4-dichlorophenoxy)-2,6-dichlorophenol (ambigol C, 1), a highly chlorinated aromatic compound, and 2,4-dichlorobenzoic acid (2) were isolated from the terrestrial cyanobacterium Fischerella ambigua together with the known compounds ambigol A (3) and tjipanazole D (4). All structures were secured by extensive spectroscopic analysis (1D and 2D NMR, MS, UV, IR). Ambigol C has moderate activity against Trypanosoma rhodesiense.

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Year:  2005        PMID: 15787461     DOI: 10.1021/np049640w

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  7 in total

Review 1.  Chemodiversity in freshwater and terrestrial cyanobacteria - a source for drug discovery.

Authors:  George E Chlipala; Shunyan Mo; Jimmy Orjala
Journal:  Curr Drug Targets       Date:  2011-10       Impact factor: 3.465

2.  Organohalide-Respiring Bacteria at the Heart of Anaerobic Metabolism in Arctic Wet Tundra Soils.

Authors:  David A Lipson; Theodore K Raab; Sherlynette Pérez Castro; Alexander Powell
Journal:  Appl Environ Microbiol       Date:  2021-01-15       Impact factor: 4.792

Review 3.  Indole Alkaloids of the Stigonematales (Cyanophyta): Chemical Diversity, Biosynthesis and Biological Activity.

Authors:  Katherine Walton; John P Berry
Journal:  Mar Drugs       Date:  2016-04-06       Impact factor: 5.118

4.  Genome mining for natural product biosynthetic gene clusters in the Subsection V cyanobacteria.

Authors:  Melinda L Micallef; Paul M D'Agostino; Deepti Sharma; Rajesh Viswanathan; Michelle C Moffitt
Journal:  BMC Genomics       Date:  2015-09-03       Impact factor: 3.969

5.  Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals.

Authors:  Lionel Sacconnay; Melissa Angleviel; Giuseppe Marco Randazzo; Marcos Marçal Ferreira Queiroz; Emerson Ferreira Queiroz; Jean-Luc Wolfender; Pierre-Alain Carrupt; Alessandra Nurisso
Journal:  PLoS Negl Trop Dis       Date:  2014-02-13

6.  Halogenation-Guided Chemical Screening Provides Insight into Tjipanazole Biosynthesis by the Cyanobacterium Fischerella ambigua.

Authors:  Tomasz Chilczuk; Till F Schäberle; Sahel Vahdati; Ute Mettal; Mustafa El Omari; Heike Enke; Michael Wiese; Gabriele M König; Timo H J Niedermeyer
Journal:  Chembiochem       Date:  2020-04-16       Impact factor: 3.164

7.  Comparative molecular docking of antitrypanosomal natural products into multiple Trypanosoma brucei drug targets.

Authors:  Ifedayo V Ogungbe; William N Setzer
Journal:  Molecules       Date:  2009-04-14       Impact factor: 4.411

  7 in total

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