Literature DB >> 15787451

Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica.

Xiao Y Wei1, Chung Y Leung, Chris K C Wong, Xiao L Shen, Ricky N S Wong, Zong W Cai, Nai K Mak.   

Abstract

A new indigoid derivative, bisindigotin (1), with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-antagonistic activity was isolated from the ethanol extract of the Chinese medicinal herb Isatis indigotica. Its structure was determined by spectroscopic methods. In the human HepG2 hepatoma cell model, 1 (50 nM to 2 microM) was found to dose-dependently inhibit TCDD-induced ethoxyresorufin O-deethylase (EROD) activity.

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Year:  2005        PMID： 15787451     DOI： 10.1021/np049662i

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Analysis of the extracts of Isatis tinctoria by new analytical approaches of HPLC, MS and NMR.

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2.  Sulfur-enriched alkaloids from the root of Isatis indigotica.

Authors:  Qinglan Guo; Chengbo Xu; Minghua Chen; Sheng Lin; Yuhuan Li; Chenggen Zhu; Jiandong Jiang; Yongchun Yang; Jiangong Shi
Journal:  Acta Pharm Sin B       Date:  2018-08-23       Impact factor: 11.413

3.  Indole alkaloid glycosides with a 1'-(phenyl)ethyl unit from Isatis indigotica leaves.

Authors:  Qinglan Guo; Dawei Li; Chengbo Xu; Chenggen Zhu; Ying Guo; Haibo Yu; Xiaoliang Wang; Jiangong Shi
Journal:  Acta Pharm Sin B       Date:  2019-09-12       Impact factor: 11.413

4.  Urease and α-Chymotrypsin Inhibitory Activities and Molecular Docking Studies of Alkaloids Isolated from Medicinal Plant Isatis minima Bunge.

Authors:  Fozia Fozia; Ijaz Ahmad; Zia Ul Haq; Abdul Wadood; Hidayat Ullah Khan; Mushtaq Ahmed; Nargis Jamila; Riaz Ullah; Amal Alotaibi; Mujeeb A Sultan
Journal:  Evid Based Complement Alternat Med       Date:  2022-06-15       Impact factor: 2.650

5.  In Silico Screening of Potential Spike Glycoprotein Inhibitors of SARS-CoV-2 with Drug Repurposing Strategy.

Authors:  Tian-Zi Wei; Hao Wang; Xue-Qing Wu; Yi Lu; Sheng-Hui Guan; Feng-Quan Dong; Chen-le Dong; Gu-Li Zhu; Yu-Zhou Bao; Jian Zhang; Guan-Yu Wang; Hai-Ying Li
Journal:  Chin J Integr Med       Date:  2020-08-01       Impact factor: 1.978

6.  Deciphering Key Pharmacological Pathways of Qingdai Acting on Chronic Myeloid Leukemia Using a Network Pharmacology-Based Strategy.

Authors:  Huayao Li; Lijuan Liu; Cun Liu; Jing Zhuang; Chao Zhou; Jing Yang; Chundi Gao; Gongxi Liu; Qingliang Lv; Changgang Sun
Journal:  Med Sci Monit       Date:  2018-08-15

7.  Microscopic Mass Spectrometry Imaging Reveals the Distribution of Phytochemicals in the Dried Root of Isatis tinctoria.

Authors:  Li-Xing Nie; Jing Dong; Lie-Yan Huang; Xiu-Yu Qian; Chao-Jie Lian; Shuai Kang; Zhong Dai; Shuang-Cheng Ma
Journal:  Front Pharmacol       Date:  2021-06-29       Impact factor: 5.810
  7 in total

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