Literature DB >> 15787450

Cytotoxic flavonoids from Platymiscium floribundum.

Maria José C Falcão1, Yvone Brígido M Pouliquem, Mary Anne S Lima, Nilce Viana Gramosa, Letícia V Costa-Lotufo, Gardênia Carmen G Militão, Cláudia Pessoa, Manoel Odorico de Moraes, Edilberto R Silveira.   

Abstract

Two new isoflavonoids, 7-hydroxy-6,4'-dimethoxy-isoflavonequinone (1) and 2'-hydroxy-6,4',6' ',4' ''-tetramethoxy-[7-O-7' ']-bisisoflavone (2), and seven other known flavonoids, 3-hydroxy-9-methoxypterocarpan (medicarpin), 3,10-dihydroxy-9-methoxypterocarpan, 3,9-dimethoxypterocarpan (homopterocarpin) (3), 2,3,9-trimethoxypterocarpan (4), 3,4-dihydroxy-9-methoxypterocarpan (vesticarpan) (5), 2',4,4'-trihydroxychalcone (isoliquiritigenin), and 7,4'-dihydroxyflavanone (liquiritigenin) (6), were isolated from the heartwood of Platymiscium floribundum. The structures of compounds 1 and 2 were established by spectroscopic methods. Compounds 3-6 showed cytotoxic activity when evaluated against five human cancer cell lines in vitro.

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Year:  2005        PMID： 15787450     DOI： 10.1021/np049854d

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

1.  Antitumor Potential of the Isoflavonoids (+)- and (-)-2,3,9-Trimethoxypterocarpan: Mechanism-of-Action Studies.

Authors:  Kaio Farias; Roner F da Costa; Assuero S Meira; Jairo Diniz-Filho; Eveline M Bezerra; Valder N Freire; Prue Guest; Maryam Nikahd; Xinghua Ma; Michael G Gardiner; Martin G Banwell; Maria da C F de Oliveira; Manoel O de Moraes; Claudia do Ó Pessoa
Journal:  ACS Med Chem Lett       Date:  2020-05-20       Impact factor: 4.345

2.  Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone.

Authors:  Nadja Soares Vila-Nova; Selene Maia de Morais; Maria José Cajazeiras Falcão; Terezinha Thaize Negreiros Alcantara; Pablito Augusto Travassos Ferreira; Eveline Solon Barreira Cavalcanti; Icaro Gusmão Pinto Vieira; Cláudio Cabral Campello; Mary Wilson
Journal:  Exp Parasitol       Date:  2012-12-08       Impact factor: 2.011

3.  Molecular docking study and antireabsorptive activity of a semi-synthetic coumarin derivative from Platymiscium floribundum in the ligature-induced periodontitis in rats: the involvement of heme oxygenase-1.

Authors:  Ana Larissa de Q França; Hellíada V Chaves; Jordânia M de O Freire; Luzia Hermínia T de Sousa; Antônia T A Pimenta; Mary Anne S Lima; Bruna R de Oliveira; Marcos Carlos de Mattos; Vicente de Paulo T Pinto; Antônia Moêmia L R Portela; Karuza Maria A Pereira; José Jackson do N Costa; Paula Goes; Roberta Jeane B Jorge; João Alison de M Silveira; Helyson Lucas B Braz; Maria Elisabete A de Moraes; Mirna M Bezerra
Journal:  Clin Oral Investig       Date:  2021-08-19       Impact factor: 3.573

Review 4.  The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence.

Authors:  Khaled A Selim; Hend Abdelrasoul; Mohamed Aboelmagd; Ahmed M Tawila
Journal:  Diseases       Date:  2017-04-26

Review 5.  Natural products as new antimitotic compounds for anticancer drug development.

Authors:  Carlos Roberto Koscky Paier; Sarah Sant'Anna Maranhão; Teiliane Rodrigues Carneiro; Lídia Moreira Lima; Danilo Damasceno Rocha; Renan da Silva Santos; Kaio Moraes de Farias; Manoel Odorico de Moraes-Filho; Claudia Pessoa
Journal:  Clinics (Sao Paulo)       Date:  2018-12-10       Impact factor: 2.365

6.  Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats.

Authors:  Jordânia M O Freire; Hellíada V Chaves; Alrieta H Teixeira; Luzia Herminia T de Sousa; Isabela Ribeiro Pinto; José Jackson do N Costa; Nayara Alves de Sousa; Karuza Maria A Pereira; Virgínia C C Girão; Vanessa C S Ferreira; João Evangelista de Ávila Dos Santos; Mary Anne S Lima; Antônia T A Pimenta; Raquel de C Montenegro; Maria Elisabete A de Moraes; Vicente de P T Pinto; Gerardo C Filho; Mirna M Bezerra
Journal:  PLoS One       Date:  2019-11-04       Impact factor: 3.240
  6 in total

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