Literature DB >> 15787443

Hemiterpene glucosides with anti-platelet aggregation activities from Ilex pubescens.

Zhi-Hong Jiang1, Jing-Rong Wang, Min Li, Zhong-Qiu Liu, Ka-Yee Chau, Chi Zhao, Liang Liu.   

Abstract

Two new hemiterpene glucosides named pubescenosides A and B were isolated from the root of Ilex pubescens. Their structures were elucidated on the basis of spectroscopic and chemical evidence as 2-(trans-caffeoyloxy)methyl-3-hydroxy-1-butene-4-O-beta-D-glucopyranoside and 2-hydroxymethyl-3-caffeoyloxy-1-butene-4-O-beta-D-glucopyranoside, respectively. Pharmacological investigation on pubescenosides A and B indicated that both possess potent anti-platelet aggregation activities.

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Year:  2005        PMID： 15787443     DOI： 10.1021/np049735y

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

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Authors:  Valery M Dembitsky
Journal:  Lipids       Date:  2006-01       Impact factor: 1.880

2.  Ilexsaponin A attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway.

Authors:  Shuang-Wei Zhang; Yu Liu; Fang Wang; Jiao Qiang; Pan Liu; Jun Zhang; Jin-Wen Xu
Journal:  PLoS One       Date:  2017-02-09       Impact factor: 3.240

3.  Rapid Screening of Potential Phosphodiesterase Inhibitors from the Roots of Ilex pubescens Hook. et Arn. Using a Combination of Ultrafiltration and LC-MS.

Authors:  Zichen Liu; Zongtao Lin; Shizhong Chen; Lingjun Wang; Shaoxiang Xian
Journal:  Evid Based Complement Alternat Med       Date:  2017-03-23       Impact factor: 2.629

4.  Intervention action of total flavonoids from root of Ilex pubescens in cerebral ischemic tolerance with blood stasis.

Authors:  Mingsan Miao; Lihua Cao; Kun Xu; Weiyun Xin; Yan Zheng
Journal:  Saudi J Biol Sci       Date:  2017-01-26       Impact factor: 4.219

5.  Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury.

Authors:  Yuanyuan Cheng; Liangkai Cheng; Xiang Gao; Sixuan Chen; Peng Wu; Caiyan Wang; Zhongqiu Liu
Journal:  Theranostics       Date:  2021-01-01       Impact factor: 11.556

6.  Pubescenosides E⁻K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity.

Authors:  Xiaoxu Qiao; Mengying Ji; Yunda Yao; Leilei Ma; Jinjun Wu; Guochao Liao; Hua Zhou; Zhongqiu Liu; Peng Wu
Journal:  Molecules       Date:  2018-06-12       Impact factor: 4.411
  6 in total

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