BACKGROUND: It has been suggested that increased hepatic and intramuscular fat is associated with insulin resistance, and that increased pancreatic fat is related to impaired insulin secretion. OBJECTIVE: We postulated that in obese nondiabetic teenagers insulin levels would be directly related to increases in intramuscular and hepatic fat and inversely related to increases in pancreatic fat. MATERIALS AND METHODS: MRI was used to assess the percentage of fat in the liver, muscle and pancreas in 15 healthy Mexican-American girls, 14-17 years old, with body mass indexes (BMIs) ranging from 17.7 kg/m(2) to 46 kg/m(2). RESULTS: Strong correlations were observed between BMI and fat content in the liver, muscle, and pancreas (r(2)s between 0.50 and 0.89; P<0.003). Serum insulin levels were closely associated with fat measures in the muscle and liver (r(2s)=0.63 and 0.29, and P=0.001 and P=0.023, respectively). In contrast to our hypothesis, fat content in the pancreas was also directly related to insulin secretion (r(2)=0.74; P=0.001). SUMMARY: We conclude that in nondiabetic teenagers, obesity is associated with an increased accumulation of fat in the pancreas without impairment of insulin secretion.
BACKGROUND: It has been suggested that increased hepatic and intramuscular fat is associated with insulin resistance, and that increased pancreatic fat is related to impaired insulin secretion. OBJECTIVE: We postulated that in obese nondiabetic teenagers insulin levels would be directly related to increases in intramuscular and hepatic fat and inversely related to increases in pancreatic fat. MATERIALS AND METHODS: MRI was used to assess the percentage of fat in the liver, muscle and pancreas in 15 healthy Mexican-American girls, 14-17 years old, with body mass indexes (BMIs) ranging from 17.7 kg/m(2) to 46 kg/m(2). RESULTS: Strong correlations were observed between BMI and fat content in the liver, muscle, and pancreas (r(2)s between 0.50 and 0.89; P<0.003). Serum insulin levels were closely associated with fat measures in the muscle and liver (r(2s)=0.63 and 0.29, and P=0.001 and P=0.023, respectively). In contrast to our hypothesis, fat content in the pancreas was also directly related to insulin secretion (r(2)=0.74; P=0.001). SUMMARY: We conclude that in nondiabetic teenagers, obesity is associated with an increased accumulation of fat in the pancreas without impairment of insulin secretion.
Authors: H Yki-Järvinen; M Kauppila; E Kujansuu; J Lahti; T Marjanen; L Niskanen; S Rajala; L Ryysy; S Salo; P Seppälä Journal: N Engl J Med Date: 1992-11-12 Impact factor: 91.245
Authors: Richard Winkelmann; Peter Börnert; Jan De Becker; Romhild Hoogeveen; Peter Mazurkewitz; Olaf Dössel Journal: MAGMA Date: 2006-11-24 Impact factor: 2.310
Authors: Wei Shen; Haiying Liu; Mark Punyanitya; Jun Chen; Steven B Heymsfield Journal: Curr Opin Clin Nutr Metab Care Date: 2005-11 Impact factor: 4.294
Authors: Anthony C Santago; Meghan E Vidt; Christopher J Tuohy; Gary G Poehling; Michael T Freehill; Jennifer H Jordan; Robert A Kraft; Katherine R Saul Journal: Ann Biomed Eng Date: 2015-10-29 Impact factor: 3.934
Authors: Andrew M Kim; Brendan T Keenan; Nicholas Jackson; Eugenia L Chan; Bethany Staley; Drew A Torigian; Abass Alavi; Richard J Schwab Journal: Am J Respir Crit Care Med Date: 2014-06-01 Impact factor: 21.405