BACKGROUND: Plasma fibrinogen may be an independent risk factor for cardiovascular disease. Cigarette smoking is a well-recognized determinant of plasma fibrinogen however it remains unclear how fibrinogen levels relate to the degree and duration of smoking, or to time since smoking cessation. METHODS: In a population-based study of 11 059 men and women aged 45-74 years, we examined the cross-sectional relationship between plasma fibrinogen and cigarette smoking habit. RESULTS: Mean fibrinogen concentrations were higher in current smokers compared to non-current smokers (men: 3.13+/-0.77 versus 2.80+/-0.71 g/l, P<0.0001; women: 3.03+/-0.72 versus 2.95+/-0.71 g/l, P=0.01), independent of age, body mass index and hormone replacement therapy in women In men, fibrinogen concentrations declined with years since stopping smoking but remained higher than in life-long non-smokers for 15 years. No relationship between fibrinogen and duration of smoking cessation was observed in women. On multivariate analysis, age, body mass index, use of hormone-replacement therapy, smoking status and pack-years of smoking were independent predictors of plasma fibrinogen. CONCLUSIONS: Plasma fibrinogen is strongly associated with cigarette smoking with a dose-response relationship with total pack-years of smoking. In men who stop smoking plasma fibrinogen may remain elevated for several years after cessation.
BACKGROUND: Plasma fibrinogen may be an independent risk factor for cardiovascular disease. Cigarette smoking is a well-recognized determinant of plasma fibrinogen however it remains unclear how fibrinogen levels relate to the degree and duration of smoking, or to time since smoking cessation. METHODS: In a population-based study of 11 059 men and women aged 45-74 years, we examined the cross-sectional relationship between plasma fibrinogen and cigarette smoking habit. RESULTS: Mean fibrinogen concentrations were higher in current smokers compared to non-current smokers (men: 3.13+/-0.77 versus 2.80+/-0.71 g/l, P<0.0001; women: 3.03+/-0.72 versus 2.95+/-0.71 g/l, P=0.01), independent of age, body mass index and hormone replacement therapy in women In men, fibrinogen concentrations declined with years since stopping smoking but remained higher than in life-long non-smokers for 15 years. No relationship between fibrinogen and duration of smoking cessation was observed in women. On multivariate analysis, age, body mass index, use of hormone-replacement therapy, smoking status and pack-years of smoking were independent predictors of plasma fibrinogen. CONCLUSIONS: Plasma fibrinogen is strongly associated with cigarette smoking with a dose-response relationship with total pack-years of smoking. In men who stop smoking plasma fibrinogen may remain elevated for several years after cessation.
Authors: Min A Jhun; Jennifer A Smith; Erin B Ware; Sharon L R Kardia; Thomas H Mosley; Stephen T Turner; Patricia A Peyser; Sung Kyun Park Journal: Am J Epidemiol Date: 2017-11-15 Impact factor: 4.897
Authors: Jens Baumert; Jie Huang; Barbara McKnight; Maria Sabater-Lleal; Maristella Steri; Audrey Y Chu; Stella Trompet; Lorna M Lopez; Myriam Fornage; Alexander Teumer; Weihong Tang; Alicja R Rudnicka; Anders Mälarstig; Jouke-Jan Hottenga; Maryam Kavousi; Jari Lahti; Toshiko Tanaka; Caroline Hayward; Jennifer E Huffman; Pierre-Emmanuel Morange; Lynda M Rose; Saonli Basu; Ann Rumley; David J Stott; Brendan M Buckley; Anton J M de Craen; Serena Sanna; Marco Masala; Reiner Biffar; Georg Homuth; Angela Silveira; Bengt Sennblad; Anuj Goel; Hugh Watkins; Martina Müller-Nurasyid; Regina Rückerl; Kent Taylor; Ming-Huei Chen; Eco J C de Geus; Albert Hofman; Jacqueline C M Witteman; Moniek P M de Maat; Aarno Palotie; Gail Davies; David S Siscovick; Ivana Kolcic; Sarah H Wild; Jaejoon Song; Wendy L McArdle; Ian Ford; Naveed Sattar; David Schlessinger; Anne Grotevendt; Maria Grazia Franzosi; Thomas Illig; Melanie Waldenberger; Thomas Lumley; Geoffrey H Tofler; Gonneke Willemsen; André G Uitterlinden; Fernando Rivadeneira; Katri Räikkönen; Daniel I Chasman; Aaron R Folsom; Gordon D Lowe; Rudi G J Westendorp; P Eline Slagboom; Francesco Cucca; Henri Wallaschofski; Rona J Strawbridge; Udo Seedorf; Wolfgang Koenig; Joshua C Bis; Kenneth J Mukamal; Jenny van Dongen; Elisabeth Widen; Oscar H Franco; John M Starr; Kiang Liu; Luigi Ferrucci; Ozren Polasek; James F Wilson; Tiphaine Oudot-Mellakh; Harry Campbell; Pau Navarro; Stefania Bandinelli; Johan Eriksson; Dorret I Boomsma; Abbas Dehghan; Robert Clarke; Anders Hamsten; Eric Boerwinkle; J Wouter Jukema; Silvia Naitza; Paul M Ridker; Henry Völzke; Ian J Deary; Alexander P Reiner; David-Alexandre Trégouët; Christopher J O'Donnell; David P Strachan; Annette Peters; Nicholas L Smith Journal: PLoS One Date: 2014-12-31 Impact factor: 3.240