BACKGROUND:Rosa roxburghii (RR) is a plant of which the fruit juice has been used as a medicinal remedy for a variety of diseases. It has been proposed that the putative beneficial properties are related to its antioxidant potential. AIM OF STUDY: We investigated the contribution of a supplemented RR fruit sample on the antioxidant status in a cohort of healthy humans. METHODS: A total of 36 young, healthy and non-smoking individuals were recruited for this randomised placebo-controlled, single-blind trial. The study was diet controlled over a five-week period with a two week run-in period before participants daily received a placebo or an encapsulated supplement of RR sample. Total antioxidant capacity, glutathione redox state, glutathione reductase, glutathione peroxidase, superoxide dismutase and 8-OHdG levels were measured. RESULTS:RR supplementation significantly increased plasma antioxidant capacity (p = 0.04) and GSH:GSSG ratios in blood (p = 0.03). No significant changes in 8-OHdG levels, total glutathione levels or antioxidant modulating enzymes were detected suggesting that the observed shift of the glutathione redox state probably occurs via the antioxidant mediated protection of GSH. CONCLUSIONS: We conclude that these findings support the putative beneficial properties that have been linked to Rosa roxburghii as a dietary supplement that can enhance antioxidant status.
RCT Entities:
BACKGROUND:Rosa roxburghii (RR) is a plant of which the fruit juice has been used as a medicinal remedy for a variety of diseases. It has been proposed that the putative beneficial properties are related to its antioxidant potential. AIM OF STUDY: We investigated the contribution of a supplemented RR fruit sample on the antioxidant status in a cohort of healthy humans. METHODS: A total of 36 young, healthy and non-smoking individuals were recruited for this randomised placebo-controlled, single-blind trial. The study was diet controlled over a five-week period with a two week run-in period before participants daily received a placebo or an encapsulated supplement of RR sample. Total antioxidant capacity, glutathione redox state, glutathione reductase, glutathione peroxidase, superoxide dismutase and 8-OHdG levels were measured. RESULTS:RR supplementation significantly increased plasma antioxidant capacity (p = 0.04) and GSH:GSSG ratios in blood (p = 0.03). No significant changes in 8-OHdG levels, total glutathione levels or antioxidant modulating enzymes were detected suggesting that the observed shift of the glutathione redox state probably occurs via the antioxidant mediated protection of GSH. CONCLUSIONS: We conclude that these findings support the putative beneficial properties that have been linked to Rosa roxburghii as a dietary supplement that can enhance antioxidant status.
Authors: Y X Ma; Y Zhu; C F Wang; Z S Wang; S Y Chen; M H Shen; J M Gan; J G Zhang; Q Gu; L He Journal: Mech Ageing Dev Date: 1997-06 Impact factor: 5.432
Authors: Lisa Davis; Welma Stonehouse; Du Toit Loots; Janine Mukuddem-Petersen; Francois H van der Westhuizen; Susanna M Hanekom; Johann C Jerling Journal: Eur J Nutr Date: 2007-03-21 Impact factor: 5.614