Literature DB >> 15781838

Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen.

S U Schuele1, C Kellinghaus, S J Shook, N Boulis, F A Bethoux, T Loddenkemper.   

Abstract

Oral and intrathecal baclofen (ITB) have been associated with epileptic seizures. The authors observed a higher incidence of epileptic seizures in 99 patients with multiple sclerosis (MS) treated with ITB vs a matched control group (7% vs 1%, p < 0.05). Three patients with MS on ITB developed status epilepticus. Seizures were often associated with additional triggering factors.

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Year:  2005        PMID： 15781838     DOI： 10.1212/01.WNL.0000154639.35941.21

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  10 in total

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2.  Local complications of adjunct intrathecal antibiotics for nosocomial meningitis associated with gram-negative pathogens: a meta-analysis.

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Review 3.  Seizures in patients with multiple sclerosis: epidemiology, pathophysiology and management.

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4.  Seizure after intrathecal baclofen bolus in a multiple sclerosis patient treated with oxcarbazepine.

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Journal:  Neurol Sci       Date:  2010-07-06       Impact factor: 3.307

5.  Treatment of seizures in the neurologic intensive care unit.

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7.  Temporal lobe cortical pathology and inhibitory GABA interneuron cell loss are associated with seizures in multiple sclerosis.

Authors:  Richard Nicholas; Roberta Magliozzi; Graham Campbell; Don Mahad; Richard Reynolds
Journal:  Mult Scler       Date:  2015-04-28       Impact factor: 6.312

8.  Entorhinal Principal Neurons Mediate Brain-stimulation Treatments for Epilepsy.

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Journal:  EBioMedicine       Date:  2016-11-23       Impact factor: 8.143

Review 9.  The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential.

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10.  Pre- and Postsynaptic Activation of GABAB Receptors Modulates Principal Cell Excitation in the Piriform Cortex.

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  10 in total

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