Literature DB >> 15781836

Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease.

Shigeto Sato1, Yoshikuni Mizuno, Nobutaka Hattori.   

Abstract

8-hydroxydeoxyguanosine (8-OHdG) has been used to evaluate oxidative stress. The authors investigated urinary 8-OHdG levels in 72 patients with Parkinson disease (PD) and in normal and disease control groups. The mean urinary 8-OHdG increased with the stage of PD and was not influenced by the current dose of DOPA. Our results suggest that urinary 8-OHdG is a potentially useful biomarker for evaluating the progression of PD.

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Year:  2005        PMID： 15781836     DOI： 10.1212/01.WNL.0000154597.24838.6B

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  30 in total

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