Literature DB >> 15781121

Calmodulin kinase signaling in heart: an intriguing candidate target for therapy of myocardial dysfunction and arrhythmias.

Mark E Anderson1.   

Abstract

The multifunctional Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) has emerged as a proarrhythmic and procardiomyopathic signal in a wide range of structural heart diseases. This review discusses CaMKII structure and function and recent evidence implicating CaMKII inhibition as a potential strategy for treating myocardial dysfunction and arrhythmias in the setting of structural heart disease.

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Year:  2005        PMID： 15781121     DOI： 10.1016/j.pharmthera.2004.11.002

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  45 in total

1.  CaMKII inhibition in heart failure, beneficial, harmful, or both.

Authors:  Jun Cheng; Lin Xu; Dongwu Lai; Arnaud Guilbert; Hyun Joung Lim; Thitima Keskanokwong; Yanggan Wang
Journal:  Am J Physiol Heart Circ Physiol       Date:  2012-01-27       Impact factor: 4.733

Review 2.  CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction.

Authors:  Chad E Grueter; Roger J Colbran; Mark E Anderson
Journal:  J Mol Med (Berl)       Date:  2006-11-21       Impact factor: 4.599

Review 3.  The L-type calcium channel in the heart: the beat goes on.

Authors:  Ilona Bodi; Gabor Mikala; Sheryl E Koch; Shahab A Akhter; Arnold Schwartz
Journal:  J Clin Invest       Date:  2005-12       Impact factor: 14.808

Review 4.  The regulation of dendritic cell function by calcium-signaling and its inhibition by microbial pathogens.

Authors:  S F Connolly; D J Kusner
Journal:  Immunol Res       Date:  2007       Impact factor: 2.829

Review 5.  Gene therapy in heart failure.

Authors:  Leif Erik Vinge; Philip W Raake; Walter J Koch
Journal:  Circ Res       Date:  2008-06-20       Impact factor: 17.367

6.  MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²⁺ overload and cell death.

Authors:  Arin B Aurora; Ahmed I Mahmoud; Xiang Luo; Brett A Johnson; Eva van Rooij; Satoshi Matsuzaki; Kenneth M Humphries; Joseph A Hill; Rhonda Bassel-Duby; Hesham A Sadek; Eric N Olson
Journal:  J Clin Invest       Date:  2012-03-19       Impact factor: 14.808

Review 7.  Rodent models of heart failure: an updated review.

Authors:  A C Gomes; I Falcão-Pires; A L Pires; C Brás-Silva; A F Leite-Moreira
Journal:  Heart Fail Rev       Date:  2013-03       Impact factor: 4.214

8.  Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium.

Authors:  Xianlong Gao; Xiaomin Wu; Jiajie Yan; Jingqun Zhang; Weiwei Zhao; Dominic DeMarco; Yongguo Zhang; Mamdouh Bakhos; Gregory Mignery; Jun Sun; Zhenyu Li; Michael Fill; Xun Ai
Journal:  Cardiovasc Res       Date:  2018-04-01       Impact factor: 10.787

Review 9.  Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases.

Authors:  A Ishida; N Sueyoshi; Y Shigeri; I Kameshita
Journal:  Br J Pharmacol       Date:  2008-05-05       Impact factor: 8.739

10.  Effects of calmodulin-dependent protein kinase II inhibitor, KN-93, on electrophysiological features of rabbit hypertrophic cardiac myocytes.

Authors:  Jun Ke; Feng Chen; Cuntai Zhang; Xing Xiao; Jing Tu; Musen Dai; Xiaoping Wang; Bing Chen; Min Chen
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2012-08-11
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