| Literature DB >> 15781034 |
Bridget A Martell1, Julia H Arnsten, Mori J Krantz, Marc N Gourevitch.
Abstract
We prospectively assessed the effect of oral methadone on the corrected QT interval (QTc) among 160 patients free of structural heart disease and measured serum methadone concentrations and simultaneous QTc intervals in a subset of 44 participants. Mean +/- SD QTc increased by 12.4 +/- 23 ms (p <0.001) at 6 months, by 10.7 +/- 30 ms (p <0.001) at 12 months, and the QTc change from baseline to 12 months correlated with the trough (r = 0.37, p = 0.008) and peak (r = 0.32, p = 0.03) serum methadone concentrations.Entities:
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Year: 2005 PMID： 15781034 DOI： 10.1016/j.amjcard.2004.11.055
Source DB: PubMed Journal: Am J Cardiol ISSN： 0002-9149 Impact factor: 2.778