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Literature DB >> 15780715

Vaccines for otitis media: proposals for overcoming obstacles to progress.

Timothy F Murphy¹, Lauren O Bakaletz, Jennelle M Kyd, Bracie Watson, David L Klein.

Abstract

Otitis media is a common problem with enormous morbidity worldwide. The development of vaccines to prevent otitis media would have an important human and economic impact. A striking lack of progress in the development, production and clinical testing of vaccines to prevent otitis media has occurred in the past decade. This review outlines a series of specific proposals intended to advance vaccine development for otitis media.

Entities: Disease Species

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Year: 2005 PMID： 15780715 DOI： 10.1016/j.vaccine.2004.12.014

Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641

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Cited

18 in total

1. Bacterial sinusitis and otitis media following influenza virus infection in ferrets.

Authors: Ville T Peltola; Kelli L Boyd; Julie L McAuley; Jerold E Rehg; Jonathan A McCullers
Journal: Infect Immun Date: 2006-05 Impact factor: 3.441

Review 2. Vaccines for Nontypeable Haemophilus influenzae: the Future Is Now.

Authors: Timothy F Murphy
Journal: Clin Vaccine Immunol Date: 2015-03-18

3. Complex role of hemoglobin and hemoglobin-haptoglobin binding proteins in Haemophilus influenzae virulence in the infant rat model of invasive infection.

Authors: Thomas W Seale; Daniel J Morton; Paul W Whitby; Roman Wolf; Stanley D Kosanke; Timothy M VanWagoner; Terrence L Stull
Journal: Infect Immun Date: 2006-09-11 Impact factor: 3.441

4. Construction of a mutant and characterization of the role of the vaccine antigen P6 in outer membrane integrity of nontypeable Haemophilus influenzae.

Authors: Timothy F Murphy; Charmaine Kirkham; Alan J Lesse
Journal: Infect Immun Date: 2006-09 Impact factor: 3.441

Review 5. Mouse models for human otitis media.

Authors: Dennis R Trune; Qing Yin Zheng
Journal: Brain Res Date: 2009-03-06 Impact factor: 3.252

10. The iron/heme regulated genes of Haemophilus influenzae: comparative transcriptional profiling as a tool to define the species core modulon.

Authors: Paul W Whitby; Thomas W Seale; Timothy M VanWagoner; Daniel J Morton; Terrence L Stull
Journal: BMC Genomics Date: 2009-01-07 Impact factor: 3.969

Vaccines for otitis media: proposals for overcoming obstacles to progress.

1. Bacterial sinusitis and otitis media following influenza virus infection in ferrets.

Review 2. Vaccines for Nontypeable Haemophilus influenzae: the Future Is Now.

3. Complex role of hemoglobin and hemoglobin-haptoglobin binding proteins in Haemophilus influenzae virulence in the infant rat model of invasive infection.

4. Construction of a mutant and characterization of the role of the vaccine antigen P6 in outer membrane integrity of nontypeable Haemophilus influenzae.

Review 5. Mouse models for human otitis media.

6. Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells.

7. A proteomic characterization of NTHi lysates.

8. Dual orientation of the outer membrane lipoprotein P6 of nontypeable haemophilus influenzae.

Review 9. Immunopathogenesis of polymicrobial otitis media.

10. The iron/heme regulated genes of Haemophilus influenzae: comparative transcriptional profiling as a tool to define the species core modulon.