Literature DB >> 15780635

Antitubercular agents. Part 2: new thiolactomycin analogues active against Mycobacterium tuberculosis.

Ahmed Kamal1, Ahmad Ali Shaik, Rakesh Sinha, J S Yadav, Sudarshan K Arora.   

Abstract

Structurally modified analogues of naturally occurring antibiotic thiolactomycin, substituted at 4-position of the thiolactone ring have been prepared and evaluated for their antitubercular activity. Some of the compounds have exhibited potential activity against Mycobacterium tuberculosis.

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Year:  2005        PMID： 15780635     DOI： 10.1016/j.bmcl.2005.01.084

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Discovery of FabH/FabF inhibitors from natural products.

Authors:  Katherine Young; Hiranthi Jayasuriya; John G Ondeyka; Kithsiri Herath; Chaowei Zhang; Srinivas Kodali; Andrew Galgoci; Ronald Painter; Vickie Brown-Driver; Robert Yamamoto; Lynn L Silver; Yingcong Zheng; Judith I Ventura; Janet Sigmund; Sookhee Ha; Angela Basilio; Francisca Vicente; José Rubén Tormo; Fernando Pelaez; Phil Youngman; Doris Cully; John F Barrett; Dennis Schmatz; Sheo B Singh; Jun Wang
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

Review 2.  Recent advances in the chemistry and biology of naturally occurring antibiotics.

Authors:  K C Nicolaou; Jason S Chen; David J Edmonds; Anthony A Estrada
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

3.  Novel route to 5-position vinyl derivatives of thiolactomycin: Olefination vs. deformylation.

Authors:  Pilho Kim; Clifton E Barry; Cynthia S Dowd
Journal:  Tetrahedron Lett       Date:  2006-05-15       Impact factor: 2.415

4.  Novel tetracyclic structures from the synthesis of thiolactone-isatin hybrids.

Authors:  Renate Hazel Hans; Hong Su; Kelly Chibale
Journal:  Beilstein J Org Chem       Date:  2010-07-19       Impact factor: 2.883

5.  Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.

Authors:  Gopal R Bommineni; Kanishk Kapilashrami; Jason E Cummings; Yang Lu; Susan E Knudson; Chendi Gu; Stephen G Walker; Richard A Slayden; Peter J Tonge
Journal:  J Med Chem       Date:  2016-05-24       Impact factor: 7.446

6.  Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH.

Authors:  Qosay Al-Balas; Nahoum G Anthony; Bilal Al-Jaidi; Amani Alnimr; Grainne Abbott; Alistair K Brown; Rebecca C Taylor; Gurdyal S Besra; Timothy D McHugh; Stephen H Gillespie; Blair F Johnston; Simon P Mackay; Geoffrey D Coxon
Journal:  PLoS One       Date:  2009-05-19       Impact factor: 3.240
  6 in total

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