| Literature DB >> 15780626 |
Anu Agarwal1, Kumkum Srivastava, S K Puri, Prem M S Chauhan.
Abstract
A series of 2,4,6-trisubstituted pyrimidines (3a-o) was synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 15 compounds synthesized 11 compounds showed MIC in the range of 0.5-2 microg/mL. These compounds are in vitro several folds more active than pyrimethamine.Entities:
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Year: 2005 PMID： 15780626 DOI： 10.1016/j.bmcl.2005.02.015
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823