Literature DB >> 15780624

Synthesis of 15R-PGD2: a potential DP2 receptor agonist.

Seongjin Kim1, Sophie Bellone, Kirk M Maxey, William S Powell, Gue-Jae Lee, Joshua Rokach.   

Abstract

The first total synthesis of 15R-PGD(2)3 was accomplished. The approach used in this report is also an efficient method to produce 15R-PGE(2). 15R-PGD(2), a potential DP(2) receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory diseases.

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Year:  2005        PMID: 15780624     DOI: 10.1016/j.bmcl.2005.02.011

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Reductive Deprotection of Silyl Groups with Wilkinson's Catalyst/Catechol Borane.

Authors:  Pranav Patel; Chih-Tsung Chang; Namin Kang; Gue-Jae Lee; William S Powell; Joshua Rokach
Journal:  Tetrahedron Lett       Date:  2007-07-23       Impact factor: 2.415

2.  Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity.

Authors:  Seema G Trivedi; Justine Newson; Ravindra Rajakariar; Thomas S Jacques; Robert Hannon; Yoshihide Kanaoka; Naomi Eguchi; Paul Colville-Nash; Derek W Gilroy
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-17       Impact factor: 11.205

  2 in total

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