| Literature DB >> 15780620 |
Vladimir V Martin1, Anca Rothe, Kyle R Gee.
Abstract
The synthesis and metal binding properties of cation-sensitive fluorescent indicators intended for biological applications are described. The increase of the crown ether ring size enhances the affinity for larger cations, but weakens the fluorescent response and selectivity. A compound having a 15-crown-5 chelator directly attached to a 2,7-difluoroxanthenone fluorophore loads into live cells and responds to sodium ion concentration changes with large fluorescence increases in the visible wavelength range.Entities:
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Year: 2005 PMID： 15780620 DOI： 10.1016/j.bmcl.2005.02.017
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823