| Literature DB >> 15780606 |
Sylvie D Barchéchath1, Rommel I Tawatao, Maripat Corr, Dennis A Carson, Howard B Cottam.
Abstract
The synthesis of several quinolinium salts and related compounds and their ability to inhibit glucocorticoid-induced apoptosis in murine thymocytes are described. Interestingly, 1-[2-methoxyimino-2-(4-pyrrolidin-1-yl-phenyl)ethyl]quinolinium bromide (11) showed a potent protective effect with an EC(50) of 0.013 microM, which was at least 300-fold more potent than the reference compound pifithrin-alpha.Entities:
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Year: 2005 PMID： 15780606 DOI： 10.1016/j.bmcl.2005.02.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823