| Literature DB >> 15780582 |
Ken-Ichi Ishibashi1, Masaharu Yoshida, Iwao Nakabayashi, Hiroyasu Shinohara, Noriko N Miura, Yoshiyuki Adachi, Naohito Ohno.
Abstract
We have recently detected an anti-beta-glucan antibody in normal human and normal mouse sera. The anti-beta-glucan antibody showed reactivity to pathogenic fungal Aspergillus and Candida cell wall glucan. Anti-beta-glucan antibody could bind whole Candida cells. It also enhanced the candidacidal activity of macrophages in vitro. The anti-beta-glucan antibody titer of DBA/2 mice intravenously administered either Candida or Aspergillus solubilized cell wall beta-glucan decreased remarkably dependent on dose. Moreover, in deep mycosis patients, the anti-beta-glucan antibody titer decreased, and this change correlated with clinical symptoms and other parameters such as C-reactive protein. It was suggested that the anti-beta-glucan antibody formed an antigen-antibody complex and participated in the immune response as a molecule recognizing pathogenic fungi.Entities:
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Year: 2005 PMID： 15780582 DOI： 10.1016/j.femsim.2004.12.012
Source DB: PubMed Journal: FEMS Immunol Med Microbiol ISSN： 0928-8244